发明授权
US6110503A Preparation of biodegradable, biocompatible microparticles containing a
biologically active agent
有权
制备含有生物活性剂的可生物降解的生物相容性微粒
- 专利标题： Preparation of biodegradable, biocompatible microparticles containing a biologically active agent
- 专利标题（中）： 制备含有生物活性剂的可生物降解的生物相容性微粒
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申请号： US263098申请日： 1999-03-05
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公开(公告)号： US6110503A公开(公告)日： 2000-08-29
- 发明人: Michael E. Rickey , J. Michael Ramstack , Danny H. Lewis
- 申请人： Michael E. Rickey , J. Michael Ramstack , Danny H. Lewis
- 申请人地址： MA Cambridge
- 专利权人： Alkermes Controlled Therapeutics Inc.
- 当前专利权人： Alkermes Controlled Therapeutics Inc.
- 当前专利权人地址： MA Cambridge
- 主分类号： A61K9/56
- IPC分类号： A61K9/56 ; A61K9/14 ; A61K9/16 ; A61K9/50 ; A61K9/58 ; A61K31/505 ; A61K31/517 ; A61K31/519 ; A61K31/529 ; A61K47/30 ; A61K47/34 ; B01J13/04 ; B01J13/06 ; B29B9/00 ; B01J13/02 ; B32B5/16 ; B32B15/02
摘要：
A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. An immiscible second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The two phases are immersed in a quench liquid that includes a quench medium and a quantity of the solvent. The quantity of the solvent is selected to control a rate of extraction of the solvent from the first phase. The first phase is isolated in the form of microparticles. Also disclosed is a microencapsulated active agent prepared by the method for preparing biodegradable, biocompatible microparticles.
公开/授权文献
- US5494816A Enhanced indole biosynthesis 公开/授权日：1996-02-27
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