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    Preparation of biodegradable, biocompatible microparticles containing a biologically active agent
    2.
    发明授权
    Preparation of biodegradable, biocompatible microparticles containing a biologically active agent 有权
    制备含有生物活性剂的可生物降解的生物相容性微粒

    公开(公告)号：US06403114B1

    公开(公告)日：2002-06-11

    申请号：US09920862

    申请日：2001-08-03

    申请人： Michael E. Rickey ,  J. Michael Ramstack ,  Danny H. Lewis

    发明人： Michael E. Rickey ,  J. Michael Ramstack ,  Danny H. Lewis

    IPC分类号： A61F200

    CPC分类号： B01J13/04 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5089 ,  A61K31/519 ,  Y10T428/2985

    摘要： A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. A second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The discontinuous first phase is separated from the continuous second phase. The residual level of solvent in the discontinuous first phase is reduced to less than about 2% by weight.

    摘要翻译： 一种制备可生物降解的生物相容性微粒的方法。 制备包含可生物降解的生物相容性聚合物，活性剂和溶剂的第一相。 准备第二阶段 第一和第二相组合形成乳液，其中第一相是不连续的，第二相是连续的。 不连续的第一相与连续的第二相分离。 不连续第一相中溶剂的残留量减少到小于约2重量％。

    Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
    4.
    发明授权
    Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent 失效
    制备延长的保质期的可生物降解的生物相容的含有生物活性剂的微粒

    公开(公告)号：US5792477A

    公开(公告)日：1998-08-11

    申请号：US850679

    申请日：1997-05-02

    申请人： Michael E. Rickey ,  J. Michael Ramstack ,  Danny H. Lewis ,  Jean Mesens

    发明人： Michael E. Rickey ,  J. Michael Ramstack ,  Danny H. Lewis ,  Jean Mesens

    IPC分类号： A61K9/56 ,  A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A61K9/58 ,  A61K31/505 ,  A61K31/517 ,  A61K31/519 ,  A61K31/529 ,  A61K47/30 ,  A61K47/34 ,  B01J13/04 ,  B01J13/06 ,  B29B9/00 ,  B01J13/02 ,  B32B5/16

    CPC分类号： B01J13/04 ,  A61K31/519 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5089 ,  Y10T428/2985

    摘要： A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymeric encapsulating binder, and an active agent having limited water solubility dissolved or dispersed in a solvent. An aqueous second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The two phases are separated. The discontinuous first phase is washed with water, or an aqueous solution of water and a solvent for residual solvent in the first phase, to reduce the level of residual solvent in the microparticles to less than about 2% by weight of the microparticles. Also disclosed are a microencapsulated drug prepared by the method for preparing biodegradable, biocompatible microparticles, and a pharmaceutical composition that includes biodegradable and biocompatible microparticles in a pharmaceutically acceptable carrier.

    摘要翻译： 一种制备可生物降解的生物相容性微粒的方法。 制备包含可生物降解的生物相容性聚合物包封粘合剂和溶解或分散在溶剂中的水溶性有限的活性剂的第一相。 制备水相第二相。 第一和第二相组合形成乳液，其中第一相是不连续的，第二相是连续的。 两个阶段分开。 不连续的第一相在第一相中用水，水溶液和残留溶剂的溶液洗涤，以将微粒中的残余溶剂的水平降低到微粒的约2重量％。 还公开了通过制备可生物降解的生物相容性微粒的方法制备的微胶囊化药物，以及包含可药用载体中可生物降解和生物相容的微粒的药物组合物。

    Preparation of biodegradable, biocompatible microparticles containing a biologically active agent
    5.
    发明授权
    Preparation of biodegradable, biocompatible microparticles containing a biologically active agent 有权
    制备含有生物活性剂的可生物降解的生物相容性微粒

    公开(公告)号：US06290983B1

    公开(公告)日：2001-09-18

    申请号：US09578717

    申请日：2000-05-26

    申请人： Michael E. Rickey ,  J. Michael Ramstack ,  Danny H. Lewis

    发明人： Michael E. Rickey ,  J. Michael Ramstack ,  Danny H. Lewis

    IPC分类号： A61F200

    CPC分类号： B01J13/04 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5089 ,  A61K31/519 ,  Y10T428/2985

    摘要： A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. A second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The discontinuous first phase is separated from the continuous second phase. The residual level of solvent in the discontinuous first phase is reduced to less than about 2% by weight.

    摘要翻译： 一种制备可生物降解的生物相容性微粒的方法。 制备包含可生物降解的生物相容性聚合物，活性剂和溶剂的第一相。 准备第二阶段 第一和第二相组合形成乳液，其中第一相是不连续的，第二相是连续的。 不连续的第一相与连续的第二相分离。 不连续第一相中溶剂的残留量减少到小于约2重量％。

    Microencapsulation process
    10.
    发明授权
    Microencapsulation process 失效
    微胶囊化方法

    公开(公告)号：US4389330A

    公开(公告)日：1983-06-21

    申请号：US194127

    申请日：1980-10-06

    申请人： Thomas R. Tice ,  Danny H. Lewis

    发明人： Thomas R. Tice ,  Danny H. Lewis

    IPC分类号： A61K9/50 ,  A61K9/16 ,  B01J13/12 ,  B01J13/14 ,  B01J13/02

    CPC分类号： B01J13/125 ,  A61K9/1694 ,  Y10S424/14

    摘要： Microcapsules laden with an active agent are prepared by a method comprising: (a) dissolving or dispersing an active agent in a solvent and dissolving a wall forming material in said solvent; (b) dispersing said solvent containing said active agent and wall forming material in a continuous-phase processing medium; (c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microcapsules containing said active agent in the suspension; and (d) extracting the remainder of the solvent from said microcapsules.

    摘要翻译： 通过包括以下方法制备负载有活性剂的微胶囊：（a）将活性剂溶解或分散在溶剂中并将壁形成材料溶解在所述溶剂中; （b）将含有所述活性剂和壁形成材料的所述溶剂分散在连续相处理介质中; （c）从步骤（b）的所述分散体中蒸发掉一部分所述溶剂，从而在悬浮液中形成含有所述活性剂的微胶囊; 和（d）从所述微胶囊中提取剩余的溶剂。