发明授权
- 专利标题： Therapeutic treatment for VEGF related ocular diseases
- 专利标题（中）： VEGF相关性眼部疾病的治疗方法
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申请号： US841739申请日： 1997-04-30
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公开(公告)号： US6114320A公开(公告)日： 2000-09-05
- 发明人: Lloyd P. Aiello , Michael R. Jirousek , George L. King , Louis Vignati , Douglas Kirk Ways
- 申请人： Lloyd P. Aiello , Michael R. Jirousek , George L. King , Louis Vignati , Douglas Kirk Ways
- 申请人地址： IN Indianapolis MA Boston
- 专利权人： Eli Lilly and Company,Joslin Diabetes Center
- 当前专利权人： Eli Lilly and Company,Joslin Diabetes Center
- 当前专利权人地址： IN Indianapolis MA Boston
- 主分类号： C07D487/22
- IPC分类号： C07D487/22 ; A61K31/00 ; A61K31/40 ; A61K31/407 ; A61K41/00 ; A61K45/00 ; A61P9/00 ; A61P27/02 ; C07D498/22 ; A61K31/33 ; A61K31/555
摘要：
A method for inhibiting VEGF stimulated endothelial cell growth, such as associated with macular degeneration, and VEGF stimulated capillary permeability, such as associated with macular edema are disclosed, particularly using the isozyme selective PKC inhibitor, (S)-3,4-[N,N'-1,1'-((2"-ethoxy)-3'"(O)-4'"-(N,N-dimethylamino)-butane)-bis-(3,3'-indoly 1)]-1(H)-pyrrole-2,5-dionehydrochloridesalt.
公开/授权文献
- USD304784S Carrying case 公开/授权日：1989-11-28
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