发明授权
- 专利标题： Phosphonomonoester nucleic acids process for their preparation and their use
- 专利标题（中）： 膦膦酸酯核酸的制备及其用途
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申请号： US196132申请日： 1998-11-20
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公开(公告)号： US6127346A公开(公告)日： 2000-10-03
- 发明人: Anuschirwan Peyman , Eugen Uhlmann , Gerhard Breipohl , Holger Wallmeier
- 申请人： Anuschirwan Peyman , Eugen Uhlmann , Gerhard Breipohl , Holger Wallmeier
- 申请人地址： DEX Frankfurt am Main
- 专利权人： Hoechst Aktiengesellschaft
- 当前专利权人： Hoechst Aktiengesellschaft
- 当前专利权人地址： DEX Frankfurt am Main
- 优先权： DEX19508923 19950313; DEX19543865 19951124
- 主分类号： A61K31/66
- IPC分类号： A61K31/66 ; A01N43/04 ; A61K31/7088 ; A61P31/16 ; A61P31/18 ; A61P35/00 ; A61P43/00 ; C07F9/38 ; C07F9/40 ; C07H19/00 ; C07H21/00 ; C07H21/02 ; C07K14/00 ; C12Q1/68 ; C12Q1/70
摘要：
Novel oligonucleotide analogs of the formula [I] are described, ##STR1## in which A, B, D, G, L, P, Q, Q', R.sup.5, R.sup.6, X, Y, Z and n are as defined in the description, which have useful physical, biological and pharmacological properties, as well as a process for their preparation. Their application relates to use as inhibitors of gene expression (antisense oligonucleotides, ribozymes, sense oligonucleotides and triplex-forming oligonucleotides), as probes for the detection of nucleic acids and as auxiliaries in molecular biology.
公开/授权文献
- US5512217A Reactor and method of use 公开/授权日：1996-04-30
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