Invention Grant
- Patent Title: Process for preparing a morphinan derivative
- Patent Title (中): 制备吗啡喃衍生物的方法
-
Application No.: US256332Application Date: 1999-02-19
-
Publication No.: US6136979APublication Date: 2000-10-24
- Inventor: Tomas Hudlicky , Gabor Butora
- Applicant: Tomas Hudlicky , Gabor Butora
- Applicant Address: MO St. Louis
- Assignee: MallincKrodt Inc.
- Current Assignee: MallincKrodt Inc.
- Current Assignee Address: MO St. Louis
- Main IPC: C07D489/02
- IPC: C07D489/02 ; C07D491/048 ; C07F7/18 ; C07D491/08 ; C07D471/08 ; C07D263/16
Abstract:
A process for preparing a morphinan derivative, by providing a dihydrofuranyl bridged tetracycle halide of the formula (19) ##STR1## wherein X is halogen, R is an alkyl group of from 1 to about 10 carbon atoms, and R.sub.1 is a protecting group; and converting the pentacycle halide into a morphinan derivative of formula (20) ##STR2## wherein R is as defined above.
Public/Granted literature
- US5094960A Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography Public/Granted day:1992-03-10
Information query
