发明授权
US6140347A Azetidine, pyrrolidine and piperidine derivatives as 5-HT receptor
agonists
失效
氮杂环丁烷，吡咯烷和哌啶衍生物作为5-HT受体激动剂
- 专利标题： Azetidine, pyrrolidine and piperidine derivatives as 5-HT receptor agonists
- 专利标题（中）： 氮杂环丁烷，吡咯烷和哌啶衍生物作为5-HT受体激动剂
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申请号： US171208申请日： 1998-10-14
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公开(公告)号： US6140347A公开(公告)日： 2000-10-31
- 发明人: Jose Luis Castro Pineiro , Andrew Madin , Joseph George Neduvelil , Graham Andrew Showell , Leslie Joseph Street , Monique Bodil Van Niel
- 申请人： Jose Luis Castro Pineiro , Andrew Madin , Joseph George Neduvelil , Graham Andrew Showell , Leslie Joseph Street , Monique Bodil Van Niel
- 申请人地址： GBX Hoddesdon
- 专利权人： Merck Sharp & Dohme Ltd.
- 当前专利权人： Merck Sharp & Dohme Ltd.
- 当前专利权人地址： GBX Hoddesdon
- 优先权： GBX9609374 19960503
- 主分类号： C07D521/00
- IPC分类号： C07D521/00 ; A61K31/445 ; A61K31/415 ; C07D401/14
摘要：
A class of compounds of formula (I) wherein Z, E, Q, T, U, V, W, M, R.sup.1, R.sup.7 and R.sup.8 are as defined herein; are selective agonists of 5-HT.sub.1 -like receptors, being potent agonists of the human 5-HT.sub.1D.alpha. receptor subtype whilst possessing at least a 10-fold selective affinity for the 5-HT.sub.1D.alpha. receptor subtype relative to the 5-HT.sub.1D.beta. subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT.sub.1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT.sub.1D receptor agonists. ##STR1##
公开/授权文献
- US5602020A Thermostable, salt tolerant, wide PH range novel chitobiase 公开/授权日：1997-02-11
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