Invention Grant
- Patent Title: Compositions of myeloid-cell-suppressive chemokines
- Patent Title (中): 骨髓细胞抑制趋化因子的组成
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Application No.: US987638Application Date: 1992-12-09
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Publication No.: US06143289APublication Date: 2000-11-07
- Inventor: Hal E. Broxmeyer , Scott Cooper , Charles Mantel , Li Lu
- Applicant: Hal E. Broxmeyer , Scott Cooper , Charles Mantel , Li Lu
- Applicant Address: IN Bloomington
- Assignee: Indiana University Foundation
- Current Assignee: Indiana University Foundation
- Current Assignee Address: IN Bloomington
- Main IPC: A61K35/28
- IPC: A61K35/28 ; A61K38/19 ; A61K38/20 ; C07K14/52 ; C12N5/0789
Abstract:
Described are preferred processes for suppressing proliferation of or for myeloprotecting myeloid cells in mammals. The processes involve the use of chemokines of the group Macrophage Inflammatory Protein-2.alpha. (MIP-2.alpha.), Platelet Factor 4 (PF4), Interleukin-8 (IL-8) and Macrophage Chemotactic and Activating Factor (MCAF), or involve the use of these chemokines or Macrophage Inflammatory Protein-1.alpha. (MIP-1.alpha.) in synergistic combinations or while they are substantially completely in monomeric form (i.e. substantially free from their polymerized or aggregated forms).
Information query
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