发明授权
- 专利标题: Method of deposition a dry powder and dispensing device
- 专利标题(中): 沉积干粉和分配装置的方法
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申请号: US187092申请日: 1998-11-05
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公开(公告)号: US6146685A公开(公告)日: 2000-11-14
- 发明人: Suggy S. Chrai , Joseph Thomas McGinn , Bawa Singh
- 申请人: Suggy S. Chrai , Joseph Thomas McGinn , Bawa Singh
- 申请人地址: NJ Monmouth Junction
- 专利权人: Delsys Pharmaceutical Corporation
- 当前专利权人: Delsys Pharmaceutical Corporation
- 当前专利权人地址: NJ Monmouth Junction
- 主分类号: A61J3/00
- IPC分类号: A61J3/00 ; A61J7/00 ; A61K9/00 ; A61M15/00 ; A61M15/02 ; B05D1/06 ; B05D1/04
摘要:
A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.