Invention Grant
- Patent Title: Antisense nucleic acid compound targeted to VEGF
- Patent Title (中): 靶向VEGF的反义核酸化合物
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Application No.: US765340Application Date: 1996-12-23
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Publication No.: US6150092APublication Date: 2000-11-21
- Inventor: Kiyoshi Uchida , Takayoshi Uchida , Youichi Tanaka , Yoko Matsuda , Shinichi Kondo
- Applicant: Kiyoshi Uchida , Takayoshi Uchida , Youichi Tanaka , Yoko Matsuda , Shinichi Kondo
- Applicant Address: JPX Tokyo
- Assignee: Taogosei Company, Ltd.
- Current Assignee: Taogosei Company, Ltd.
- Current Assignee Address: JPX Tokyo
- Priority: JPX6-145146 19940627; JPX6-311130 19941121
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C12N15/113 ; G01N33/564 ; G01N33/574 ; G01N33/74 ; C07H21/04 ; C12N15/85 ; C12Q1/68
Abstract:
The present invention relates to an antisense nucleic acid compound which has a nucleotide sequence complementary to at least 8 contiguous nucleotides in the nucleotide sequence of a gene coding for a vascular endothelial growth factor and which inhibits the expression of the vascular endothelial growth factor, as well as to a therapeutic or diagnostic agent for cancers, rheumatoid arthritis, diabetes etc., comprising said antisense nucleic acid as active ingredient. Further, the present invention relates to a method of preventing the expression of the vascular endothelial growth factor, comprising use of an antisense nucleic acid compound which has a nucleotide sequence complementary to at least 8 contiguous nucleotides in the nucleotide sequence of a gene coding for a vascular endothelial growth factor and which inhibits the expression of the vascular endothelial growth factor.
Public/Granted literature
- US5172848A Method and apparatus for convection brazing of aluminum heat exchangers Public/Granted day:1992-12-22
Information query
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