发明授权
- 专利标题： Nucleic acid that encodes a chimeric adenoviral coat protein
- 专利标题（中）： 编码嵌合腺病毒外壳蛋白的核酸
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申请号： US335411申请日： 1999-06-17
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公开(公告)号： US6153435A公开(公告)日： 2000-11-28
- 发明人: Ronald G. Crystal , Erik Falck-Pedersen , Jason Gall , Imre Kovesdi , Thomas J. Wickham
- 申请人： Ronald G. Crystal , Erik Falck-Pedersen , Jason Gall , Imre Kovesdi , Thomas J. Wickham
- 申请人地址： NY Ithaca MD Gaithersburg
- 专利权人： Cornell Research Foundation, Inc.,GenVec, Inc.
- 当前专利权人： Cornell Research Foundation, Inc.,GenVec, Inc.
- 当前专利权人地址： NY Ithaca MD Gaithersburg
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K35/76 ; A61K48/00 ; C07K14/075 ; C07K19/00 ; C12N5/10 ; C12N7/00 ; C12N15/34 ; C12N15/861 ; C12N15/64 ; C12N1/00 ; C12N15/63
摘要：
The present invention provides a chimeric adenoviral coat protein (particularly a chimeric adenovirus hexon and/or fiber protein). The chimeric adenovirus coat protein has a decreased ability or inability to be recognized by a neutralizing antibody directed against the corresponding wild-type adenovirus coat protein. The invention also provides an adenovirus comprising a chimeric adenovirus coat protein, and methods of constructing and using such an adenovirus, for instance, in gene therapy.
公开/授权文献
- US5622935A Medicine for preventing and curing bone fracture 公开/授权日：1997-04-22
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