Invention Grant
US6153441A Methods of screening for agonists and antagonists for human CCR7
receptor and CK.beta.-9 ligand and interaction thereof
失效
筛选人CCR7受体和CKβ-9配体的激动剂和拮抗剂的方法及其相互作用
- Patent Title: Methods of screening for agonists and antagonists for human CCR7 receptor and CK.beta.-9 ligand and interaction thereof
- Patent Title (中): 筛选人CCR7受体和CKβ-9配体的激动剂和拮抗剂的方法及其相互作用
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Application No.: US251545Application Date: 1999-02-17
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Publication No.: US6153441APublication Date: 2000-11-28
- Inventor: Edward R. Appelbaum , Henry M. Sarau , John R. White
- Applicant: Edward R. Appelbaum , Henry M. Sarau , John R. White
- Applicant Address: PA Philadelphia
- Assignee: SmithKline Beecham Corporation
- Current Assignee: SmithKline Beecham Corporation
- Current Assignee Address: PA Philadelphia
- Main IPC: G01N33/68
- IPC: G01N33/68 ; G01N33/566 ; C12P21/02 ; C12P21/06 ; G01N33/53 ; G01N33/567
Abstract:
Disclosed are methods for discovering agonists and antagonists of the interaction between a secreted human protein, chemokine CK.beta.-9, and its cellular receptor, human CCR7, which may have utility in the treatment of several human diseases, including, but not limited to: allergic disorders, autoimmune diseases, ischemia/reperfusion injury, development of atherosclerotic plaques, cancer (including mobilization of hematopoietic stem cells for use in chemotherapy or mycloprotection during chemotherapy), chronic inflammatory disorders, chronic rejection of transplanted organs or tissue grafts, chronic myelogenous leukemia, and infection by HIV and other pathogens.
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