Invention Grant
US6153652A N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical
compositions comprising same, and methods for inhibiting .beta.-amyloid
peptide release and/or its synthesis by use of such compounds
失效
N-（芳基/杂芳基/烷基乙酰基）氨基酸酰胺，包含其的药物组合物，以及通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法
- Patent Title: N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting .beta.-amyloid peptide release and/or its synthesis by use of such compounds
- Patent Title (中): N-（芳基/杂芳基/烷基乙酰基）氨基酸酰胺，包含其的药物组合物，以及通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法
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Application No.: US976295Application Date: 1997-11-21
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Publication No.: US6153652APublication Date: 2000-11-28
- Inventor: Jing Wu , Jay S. Tung , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Clark N. Eid , James E. Audia
- Applicant: Jing Wu , Jay S. Tung , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Clark N. Eid , James E. Audia
- Applicant Address: CA South San Francisco IN Indianapolis
- Assignee: Elan Pharmaceuticals, Inc.,Eli Lilly & Company
- Current Assignee: Elan Pharmaceuticals, Inc.,Eli Lilly & Company
- Current Assignee Address: CA South San Francisco IN Indianapolis
- Main IPC: A61K31/198
- IPC: A61K31/198 ; A61K31/223 ; A61K31/277 ; A61K31/44 ; A01N37/18 ; A01N37/12 ; A01N37/44 ; A61K31/165
Abstract:
Disclosed are compounds which inhibit .beta.-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits .beta.-amyloid peptide release and/or its synthesis as well as methods for treating Alheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
Public/Granted literature
- US5338631A Method of forming color images Public/Granted day:1994-08-16
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