发明授权
US6156790A C-10 carbon-substituted artemisinin-like trioxane compounds having
antimalarial, antiproliferative and antitumor activities
失效
具有抗疟疾，抗增殖和抗肿瘤活性的C-10碳取代的青蒿素样三恶烷化合物
- 专利标题： C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities
- 专利标题（中）： 具有抗疟疾，抗增殖和抗肿瘤活性的C-10碳取代的青蒿素样三恶烷化合物
-
申请号： US1242申请日： 1997-12-30
-
公开(公告)号： US6156790A公开(公告)日： 2000-12-05
- 发明人: Gary H. Posner , Soon Hyung Woo , Poonsakdi Ploypradith , Michael H. Parker , Theresa A. Shapiro , Qun Y. Zheng , Christopher Murray , Randall J. Daughenbaugh
- 申请人： Gary H. Posner , Soon Hyung Woo , Poonsakdi Ploypradith , Michael H. Parker , Theresa A. Shapiro , Qun Y. Zheng , Christopher Murray , Randall J. Daughenbaugh
- 申请人地址： CO Boulder MD Baltimore
- 专利权人： Hauser, Inc.,Johns Hopkins University
- 当前专利权人： Hauser, Inc.,Johns Hopkins University
- 当前专利权人地址： CO Boulder MD Baltimore
- 主分类号： C07D493/20
- IPC分类号： C07D493/20 ; C07D519/00 ; A61K31/335 ; C07D493/18
摘要：
The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: ##STR1## wherein, when n is 1, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, acetylenics, or benzoylmethylenes, or alkanoylmethylenes; or when n is 2, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes.
公开/授权文献
- USD347740S Chair 公开/授权日：1994-06-14
信息查询
