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    Artemisinin analogs having antimalarial, antiproliferative, and antitumor activities and chemoselective methods of making the same
    6.
    发明授权
    Artemisinin analogs having antimalarial, antiproliferative, and antitumor activities and chemoselective methods of making the same 有权
    具有抗疟疾，抗增殖和抗肿瘤活性的青蒿素类似物和制备相同的化学选择性方法

    公开(公告)号：US06586464B2

    公开(公告)日：2003-07-01

    申请号：US09887922

    申请日：2001-06-22

    申请人： Gary H. Posner ,  Hardwin O'Dowd ,  Suji Xie ,  Theresa A. Shapiro ,  Christopher Murray

    发明人： Gary H. Posner ,  Hardwin O'Dowd ,  Suji Xie ,  Theresa A. Shapiro ,  Christopher Murray

    IPC分类号： C07D51900

    CPC分类号： C07D493/18 ,  C07D519/00

    摘要： Methods for producing novel artemisinin analogs and artemisinin dimers having antimalarial, antiproliferative and antitumor activities are described herein. These novel artemisinin analogs and artemisinin dimers have the following structure or diastereomers thereof, having antimalarial, and antiproliferative and antitumor activities wherein, the monomers of the present invention are formed when n is I and R is alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl. The dimers of the present invention are formed when n is 2 and R is a linker including, but not limited to, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl.

    摘要翻译： 本文描述了具有抗疟疾，抗增殖和抗肿瘤活性的新型青蒿素类似物和青蒿素二聚体的生产方法。 这些新型青蒿素类似物和青蒿素二聚体具有以下结构的非对映异构体，具有抗疟和抗增殖和抗肿瘤活性，其中当n为I时，本发明的单体形成，R为烷基，环烷基，杂烷基，杂环烷基，烯基，炔基 ，芳基或杂芳基。 本发明的二聚体在n为2时形成，R为包括但不限于烷基，环烷基，杂烷基，杂环烷基，烯基，炔基，芳基或杂芳基的连接体。

    Artemisinin analogs having antimalarial antiproliferative and antitumor activities and chemoselective methods of making the same
    7.
    发明授权
    Artemisinin analogs having antimalarial antiproliferative and antitumor activities and chemoselective methods of making the same 失效
    具有抗疟疾抗增殖和抗肿瘤活性的青蒿素类似物和制备相同的化学选择性方法

    公开(公告)号：US06297272B1

    公开(公告)日：2001-10-02

    申请号：US09228668

    申请日：1999-01-12

    申请人： Gary H. Posner ,  Hardwin O'Dowd ,  Suji Xie ,  Theresa A. Shapiro ,  Christopher Murray

    发明人： Gary H. Posner ,  Hardwin O'Dowd ,  Suji Xie ,  Theresa A. Shapiro ,  Christopher Murray

    IPC分类号： A61K21357

    CPC分类号： C07D493/18 ,  C07D519/00

    摘要： Methods for producing novel artemisinin analogs and artemisinin dimers having antimalarial, antiproliferative and antitumor activities are described herein. These novel artemisinin analogs and artemisinin dimers have the following structure or diastereomers thereof, having antimalarial, and antiproliferative and antitumor activities wherein, the monomers of the present invention are formed when n is 1 and R is alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl. The dimers of the present invention are formed when n is 2 and R is a linker including, but not limited to, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl.

    摘要翻译： 本文描述了具有抗疟疾，抗增殖和抗肿瘤活性的新型青蒿素类似物和青蒿素二聚体的生产方法。 这些新型青蒿素类似物和青蒿素二聚体具有以下结构的非对映体，具有抗疟疾和抗增殖和抗肿瘤活性，其中当n为1时，本发明的单体形成，R为烷基，环烷基，杂烷基，杂环烷基，烯基，炔基 ，芳基或杂芳基。 本发明的二聚体在n为2时形成，R为包括但不限于烷基，环烷基，杂烷基，杂环烷基，烯基，炔基，芳基或杂芳基的连接体。

    Scrubbing device
    8.
    发明授权
    Scrubbing device 有权
    擦洗装置

    公开(公告)号：US08122554B2

    公开(公告)日：2012-02-28

    申请号：US11874390

    申请日：2007-10-18

    申请人： Ryan A. Schemmel ,  Christopher Murray ,  Mark Stratford ,  Benjamin J. Strutt ,  Patrick Marcil

    发明人： Ryan A. Schemmel ,  Christopher Murray ,  Mark Stratford ,  Benjamin J. Strutt ,  Patrick Marcil

    IPC分类号： A46B13/04 ,  A47L11/14 ,  A47L11/18

    CPC分类号： A47L13/26 ,  A46B13/001 ,  Y10T29/53

    摘要： An apparatus with a main unit, a dispenser, a clamp and a clamp structure. The main unit includes a housing, a battery in the housing, a motor in the housing and connected to the battery, and an output drive shaft driven by the motor. The dispenser includes a body that defines a body aperture and which has a reservoir for storing a fluid, and a nozzle in fluid communication with the reservoir. The dispenser is configured to permit the stored fluid to be dispensed from the reservoir through the nozzle. The clamp is coupled to either the main unit or the dispenser and includes a pivotable engagement member. The clamp structure is coupled to the other one of the main unit and the dispenser and includes a second engagement member that can be releasably engaged to the engagement member. The housing is received through the body aperture.

    摘要翻译： 具有主单元，分配器，夹具和夹具结构的设备。 主单元包括壳体，壳体中的电池，壳体中的电动机并连接到电池，以及由电动机驱动的输出驱动轴。 分配器包括限定主体孔的主体，其具有用于存储流体的储存器和与储存器流体连通的喷嘴。 分配器被配置为允许储存的流体通过喷嘴从储存器分配。 夹具联接到主单元或分配器，并且包括可枢转的接合构件。 夹具结构联接到主单元和分配器中的另一个，并且包括能够可释放地接合到接合构件的第二接合构件。 外壳通过身体孔径接收。

    System sending behavior modification hint to client to suggest alternative servers based on operating conditions of current server
    9.
    发明授权
    System sending behavior modification hint to client to suggest alternative servers based on operating conditions of current server 有权
    系统发送行为修改提示客户端根据当前服务器的运行条件建议替代服务器

    公开(公告)号：US07752630B2

    公开(公告)日：2010-07-06

    申请号：US12194434

    申请日：2008-08-19

    申请人： Christopher Murray ,  John Zamick

    发明人： Christopher Murray ,  John Zamick

    IPC分类号： G06F15/173

    CPC分类号： H04L67/1008 ,  H04L29/06 ,  H04L63/0892 ,  H04L67/1002 ,  H04L67/101 ,  H04L67/1025 ,  H04L67/1029 ,  H04L67/1034 ,  H04L67/1036 ,  H04L2029/06054

    摘要： Techniques for adaptive load balancing using behavior modification hints are disclosed, including, in at least one embodiment, monitoring a server's operating conditions; determining, based on the server's operating conditions, when to send a behavior modification hint to one or more clients that are being served by the server; generating the behavior modification hint based on the server's operating conditions; and sending the behavior modification hint to the one or more clients. In at least one embodiment, a client receives the behavior modification hint and, based on the behavior modification hint, alters a timeout value related to the server or alters its preferred server.

    摘要翻译： 公开了使用行为修改提示的自适应负载平衡的技术，包括在至少一个实施例中监视服务器的操作条件; 基于服务器的操作条件确定何时向由服务器服务的一个或多个客户端发送行为修改提示; 根据服务器的运行状况生成行为修改提示; 并向一个或多个客户端发送行为修改提示。 在至少一个实施例中，客户端接收行为修改提示，并且基于行为修改提示改变与服务器相关的超时值或改变其优选服务器。