发明授权
- 专利标题： 17q-linked breast and ovarian cancer susceptibility gene
- 专利标题（中）： 17q连锁乳腺癌和卵巢癌易感基因
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申请号： US850727申请日： 1997-05-02
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公开(公告)号： US6162897A公开(公告)日： 2000-12-19
- 发明人: Mark H. Skolnick , David E. Goldgar , Yoshio Miki , Jeff Swenson , Alexander Kamb , Keith D. Harshman , Donna M. Shattuck-Eidens , Sean V. Tavtigian , Roger W. Wiseman , P. Andrew Futreal
- 申请人： Mark H. Skolnick , David E. Goldgar , Yoshio Miki , Jeff Swenson , Alexander Kamb , Keith D. Harshman , Donna M. Shattuck-Eidens , Sean V. Tavtigian , Roger W. Wiseman , P. Andrew Futreal
- 申请人地址： UT Salt Lake City UT Salt Lake City DC Washington
- 专利权人： Myriad Genetics, Inc.,University of Utah Research Foundation,The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： Myriad Genetics, Inc.,University of Utah Research Foundation,The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： UT Salt Lake City UT Salt Lake City DC Washington
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K48/00 ; C07K14/47 ; C07K14/82 ; C12N15/12 ; C12Q1/68 ; C07K1/00 ; A01N37/18 ; A61K39/395 ; G01N33/53
摘要：
The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. Additionally, the invention relates to somatic mutations in the BRCA1 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA1 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA1 gene for mutations, which are useful for diagnosing the predisposition to breast and ovarian cancer.
公开/授权文献
- US4777019A Biosensor 公开/授权日：1988-10-11