公开(公告)号：US5443978A

公开(公告)日：1995-08-22

申请号：US82844

申请日：1993-06-25

申请人： Suzanne R. Ellenberger ,  Galen D. Peiser ,  Russell N. Bell ,  Charles E. Hussey, Jr. ,  Donna M. Shattuck-Eidens ,  Bradley D. Swedlund

发明人： Suzanne R. Ellenberger ,  Galen D. Peiser ,  Russell N. Bell ,  Charles E. Hussey, Jr. ,  Donna M. Shattuck-Eidens ,  Bradley D. Swedlund

IPC分类号： C12N15/09 ,  C12N1/19 ,  C12N1/21 ,  C12N9/10 ,  C12N15/54 ,  C12P9/00 ,  C12R1/19 ,  C12R1/865

CPC分类号： C12N9/1085

摘要： This invention provides a purified chrysanthemyl diphosphate synthase (CDS), a method for the purification of CDS from Chrysanthemum cinerariaefolium, and an amino acid sequence of the isolated CDS. Also provided is a cDNA encoding the CDS, a nucleotide sequence of the CDS gene, and a derived amino acid sequence of the encoded CDS protein. The CDS gene is useful in the enzymatic production of the natural stereospecific configuration of chrysanthemyl derivatives which are useful for the synthesis of pyrethrins, pyrethroids, derivatives thereof, as well as other classes of metabolites.

摘要翻译： 本发明提供了一种纯化的菊花二磷酸合成酶（CDS），一种从菊花中纯化CDS的方法和分离的CDS的氨基酸序列。 还提供了编码CDS的cDNA，CDS基因的核苷酸序列和编码的CDS蛋白的衍生氨基酸序列。 CDS基因可用于天然立体特异性构型的菊花衍生物的酶促生产，其可用于合成除虫菊酯，拟除虫菊酯，其衍生物以及其它类别的代谢物。

公开(公告)号：US6162897A

公开(公告)日：2000-12-19

申请号：US850727

申请日：1997-05-02

申请人： Mark H. Skolnick ,  David E. Goldgar ,  Yoshio Miki ,  Jeff Swenson ,  Alexander Kamb ,  Keith D. Harshman ,  Donna M. Shattuck-Eidens ,  Sean V. Tavtigian ,  Roger W. Wiseman ,  P. Andrew Futreal

发明人： Mark H. Skolnick ,  David E. Goldgar ,  Yoshio Miki ,  Jeff Swenson ,  Alexander Kamb ,  Keith D. Harshman ,  Donna M. Shattuck-Eidens ,  Sean V. Tavtigian ,  Roger W. Wiseman ,  P. Andrew Futreal

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/82 ,  C12N15/12 ,  C12Q1/68 ,  C07K1/00 ,  A01N37/18 ,  A61K39/395 ,  G01N33/53

CPC分类号： C07K14/4703 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4702 ,  C07K14/82 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/172

摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. Additionally, the invention relates to somatic mutations in the BRCA1 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA1 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA1 gene for mutations, which are useful for diagnosing the predisposition to breast and ovarian cancer.

摘要翻译： 本发明一般涉及人类遗传学领域。 具体地，本发明涉及用于分离和检测人乳腺癌和卵巢癌易感基因（BRCA1）的一些突变等位基因，特别是乳腺癌和卵巢癌的易感性的突变等位基因的方法和材料。 更具体地，本发明涉及BRCA1基因中的种系突变及其在诊断乳腺癌和卵巢癌易感性中的用途。 本发明还涉及人乳腺癌和卵巢癌中BRCA1基因的体细胞突变及其在人乳腺癌和卵巢癌诊断和预后中的应用。 另外本发明涉及其他人类癌症中BRCA1基因的体细胞突变及其在人类癌症诊断和预后中的应用。 本发明还涉及在BRCA1基因中具有突变的人类癌症的治疗，包括基因治疗，蛋白质替代疗法和蛋白质模拟物。 本发明还涉及用于癌症治疗的药物的筛选。 最后，本发明涉及用于突变的BRCA1基因的筛选，其可用于诊断乳腺和卵巢癌的易感性。

公开(公告)号：US5710001A

公开(公告)日：1998-01-20

申请号：US487002

申请日：1995-06-07

申请人： Mark H. Skolnick ,  David E. Goldgar ,  Yoshio Miki ,  Jeff Swenson ,  Alexander Kamb ,  Keith D. Harshman ,  Donna M. Shattuck-Eidens ,  Sean V. Tavtigian ,  Roger W. Wiseman ,  P. Andrew Futreal

发明人： Mark H. Skolnick ,  David E. Goldgar ,  Yoshio Miki ,  Jeff Swenson ,  Alexander Kamb ,  Keith D. Harshman ,  Donna M. Shattuck-Eidens ,  Sean V. Tavtigian ,  Roger W. Wiseman ,  P. Andrew Futreal

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/82 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

CPC分类号： C07K14/4703 ,  C07K14/82 ,  C12Q1/6886 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C12Q2600/136 ,  C12Q2600/172

摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. Additionally, the invention relates to somatic mutations in the BRCA1 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA1 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA1 gene for mutations, which are useful for diagnosing the predisposition to breast and ovarian cancer.

公开(公告)号：US5709999A

公开(公告)日：1998-01-20

申请号：US483553

申请日：1995-06-07

申请人： Donna M. Shattuck-Eidens ,  Jacques Simard ,  Francine Durocher ,  Mitsuuru Emi ,  Yusuke Nakamura

发明人： Donna M. Shattuck-Eidens ,  Jacques Simard ,  Francine Durocher ,  Mitsuuru Emi ,  Yusuke Nakamura

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/82 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

CPC分类号： C07K14/82 ,  C07K14/4703 ,  C12Q1/6886 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C12Q2600/136 ,  C12Q2600/172

摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. Additionally, the invention relates to somatic mutations in the BRCA1 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA1 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA1 gene for mutations, which are useful for diagnosing the predisposition to breast and ovarian cancer.

摘要翻译： 本发明一般涉及人类遗传学领域。 具体地，本发明涉及用于分离和检测人乳腺癌和卵巢癌易感基因（BRCA1）的一些突变等位基因，特别是乳腺癌和卵巢癌的易感性的突变等位基因的方法和材料。 更具体地，本发明涉及BRCA1基因中的种系突变及其在诊断乳腺癌和卵巢癌易感性中的用途。 本发明还涉及人乳腺癌和卵巢癌中BRCA1基因的体细胞突变及其在人乳腺癌和卵巢癌诊断和预后中的应用。 另外本发明涉及其他人类癌症中BRCA1基因的体细胞突变及其在人类癌症诊断和预后中的应用。 本发明还涉及在BRCA1基因中具有突变的人类癌症的治疗，包括基因治疗，蛋白质替代疗法和蛋白质模拟物。 本发明还涉及用于癌症治疗的药物的筛选。 最后，本发明涉及用于突变的BRCA1基因的筛选，其可用于诊断乳腺和卵巢癌的易感性。

公开(公告)号：US5753441A

公开(公告)日：1998-05-19

申请号：US488011

申请日：1996-01-05

申请人： Mark H. Skolnick ,  David E. Goldgar ,  Yoshio Miki ,  Jeff Swenson ,  Alexander Kamb ,  Keith D. Harshman ,  Donna M. Shattuck-Eidens ,  Sean V. Tavtigian ,  Roger W. Wiseman ,  P. Andrew Futreal

发明人： Mark H. Skolnick ,  David E. Goldgar ,  Yoshio Miki ,  Jeff Swenson ,  Alexander Kamb ,  Keith D. Harshman ,  Donna M. Shattuck-Eidens ,  Sean V. Tavtigian ,  Roger W. Wiseman ,  P. Andrew Futreal

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/82 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

CPC分类号： C07K14/82 ,  C07K14/4703 ,  C12Q1/6886 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C12Q2600/156 ,  C12Q2600/172

摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. Additionally, the invention relates to somatic mutations in the BRCA1 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA1 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA1 gene for mutations, which are useful for diagnosing the predisposition to breast and ovarian cancer.

摘要翻译： 本发明一般涉及人类遗传学领域。 具体地，本发明涉及用于分离和检测人乳腺癌和卵巢癌易感基因（BRCA1）的一些突变等位基因，特别是乳腺癌和卵巢癌的易感性的突变等位基因的方法和材料。 更具体地，本发明涉及BRCA1基因中的种系突变及其在诊断乳腺癌和卵巢癌易感性中的用途。 本发明还涉及人乳腺癌和卵巢癌中BRCA1基因的体细胞突变及其在人乳腺癌和卵巢癌诊断和预后中的应用。 另外本发明涉及其他人类癌症中BRCA1基因的体细胞突变及其在人类癌症诊断和预后中的应用。 本发明还涉及在BRCA1基因中具有突变的人类癌症的治疗，包括基因治疗，蛋白质替代疗法和蛋白质模拟物。 本发明还涉及用于癌症治疗的药物的筛选。 最后，本发明涉及用于突变的BRCA1基因的筛选，其可用于诊断乳腺和卵巢癌的易感性。

公开(公告)号：US5747282A

公开(公告)日：1998-05-05

申请号：US483554

申请日：1995-06-07

申请人： Mark H. Skolnick ,  David E. Goldgar ,  Yoshio Miki ,  Jeff Swenson ,  Alexander Kamb ,  Keith D. Harshman ,  Donna M. Shattuck-Eidens ,  Sean V. Tavtigian ,  Roger W. Wiseman ,  P. Andrew Futreal

发明人： Mark H. Skolnick ,  David E. Goldgar ,  Yoshio Miki ,  Jeff Swenson ,  Alexander Kamb ,  Keith D. Harshman ,  Donna M. Shattuck-Eidens ,  Sean V. Tavtigian ,  Roger W. Wiseman ,  P. Andrew Futreal

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/82 ,  C12N15/12 ,  C12Q1/68 ,  C12P21/06 ,  C07H21/04

CPC分类号： C07K14/4703 ,  C07K14/4702 ,  C07K14/82 ,  C12Q1/6886 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C12Q2600/136 ,  C12Q2600/172

摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. Additionally, the invention relates to somatic mutations in the BRCA1 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA1 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA1 gene for mutations, which are useful for diagnosing the predisposition to breast and ovarian cancer.

摘要翻译： 本发明一般涉及人类遗传学领域。 具体地，本发明涉及用于分离和检测人乳腺癌和卵巢癌易感基因（BRCA1）的一些突变等位基因，特别是乳腺癌和卵巢癌的易感性的突变等位基因的方法和材料。 更具体地，本发明涉及BRCA1基因中的种系突变及其在诊断乳腺癌和卵巢癌易感性中的用途。 本发明还涉及人乳腺癌和卵巢癌中BRCA1基因的体细胞突变及其在人乳腺癌和卵巢癌诊断和预后中的应用。 另外本发明涉及其他人类癌症中BRCA1基因的体细胞突变及其在人类癌症诊断和预后中的应用。 本发明还涉及在BRCA1基因中具有突变的人类癌症的治疗，包括基因治疗，蛋白质替代疗法和蛋白质模拟物。 本发明还涉及用于癌症治疗的药物的筛选。 最后，本发明涉及用于突变的BRCA1基因的筛选，其可用于诊断乳腺和卵巢癌的易感性。

公开(公告)号：US5693473A

公开(公告)日：1997-12-02

申请号：US480784

申请日：1995-06-07

申请人： Donna M. Shattuck-Eidens ,  Jacques Simard ,  Francine Durocher ,  Mitsuuru Emi ,  Yusuke Nakamura

发明人： Donna M. Shattuck-Eidens ,  Jacques Simard ,  Francine Durocher ,  Mitsuuru Emi ,  Yusuke Nakamura

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/82 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

CPC分类号： C07K14/4703 ,  C07K14/82 ,  C12Q1/6886 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C12Q2600/136 ,  C12Q2600/172

摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. Additionally, the invention relates to somatic mutations in the BRCA1 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA1 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA1 gene for mutations, which are useful for diagnosing the predisposition to breast and ovarian cancer.

摘要翻译： 本发明一般涉及人类遗传学领域。 具体地，本发明涉及用于分离和检测人乳腺癌和卵巢癌易感基因（BRCA1）的一些突变等位基因，特别是乳腺癌和卵巢癌的易感性的突变等位基因的方法和材料。 更具体地，本发明涉及BRCA1基因中的种系突变及其在诊断乳腺癌和卵巢癌易感性中的用途。 本发明还涉及人乳腺癌和卵巢癌中BRCA1基因的体细胞突变及其在人乳腺癌和卵巢癌诊断和预后中的应用。 另外本发明涉及其他人类癌症中BRCA1基因的体细胞突变及其在人类癌症诊断和预后中的应用。 本发明还涉及在BRCA1基因中具有突变的人类癌症的治疗，包括基因治疗，蛋白质替代疗法和蛋白质模拟物。 本发明还涉及用于癌症治疗的药物的筛选。 最后，本发明涉及用于突变的BRCA1基因的筛选，其可用于诊断乳腺和卵巢癌的易感性。