- 专利标题： Heterocyclic metalloprotease inhibitors
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申请号： US921953申请日： 1997-08-26
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公开(公告)号： US6166005A公开(公告)日： 2000-12-26
- 发明人: Biswanath De , Stanislaw Pikul , Menyan Cheng , Neil Gregory Almstead , Randall Stryker Matthews , Michael George Natchus , Yetunde Olabisi Taiwo
- 申请人： Biswanath De , Stanislaw Pikul , Menyan Cheng , Neil Gregory Almstead , Randall Stryker Matthews , Michael George Natchus , Yetunde Olabisi Taiwo
- 专利权人： The Procter & Gamble Company
- 当前专利权人： The Procter & Gamble Company
- 主分类号： C07D243/08
- IPC分类号： C07D243/08 ; A61K31/395 ; A61K31/495 ; A61K31/496 ; A61K31/535 ; A61K31/54 ; A61K31/554 ; A61P1/02 ; A61P1/16 ; A61P9/10 ; A61P11/00 ; A61P15/00 ; A61P17/02 ; A61P17/06 ; A61P17/16 ; A61P19/02 ; A61P19/04 ; A61P19/08 ; A61P19/10 ; A61P27/02 ; A61P29/00 ; A61P31/12 ; A61P31/18 ; A61P35/00 ; A61P35/04 ; A61P37/02 ; A61P39/00 ; A61P43/00 ; C07D223/06 ; C07D241/04 ; C07D241/08 ; C07D265/30 ; C07D279/12 ; C07D281/00 ; C07D281/06 ; C07D401/06 ; C07D401/12 ; C07D403/12 ; C07D405/06 ; C07D409/06 ; C07D413/06 ; C07D413/12 ; C07D417/04 ; C07D417/06 ; C07D417/12 ; A61K31/55 ; C07D28/106
摘要：
The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.