发明授权
- 专利标题： Aminoquanidine carboxylates for the treatment of obesity
- 专利标题（中）： 氨基胍羧酸盐治疗肥胖症
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申请号： US952717申请日： 1997-05-22
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公开(公告)号： US6166080A公开(公告)日： 2000-12-26
- 发明人: Scott D. Larsen , Paul D. May , Steven P. Tanis , Valerie A. Vaillancourt , John A. Tucker , Heinrich J. Schostarez , Martin D. Meglasson
- 申请人： Scott D. Larsen , Paul D. May , Steven P. Tanis , Valerie A. Vaillancourt , John A. Tucker , Heinrich J. Schostarez , Martin D. Meglasson
- 申请人地址： MI Kalamazoo
- 专利权人： Pharmacia
- 当前专利权人： Pharmacia
- 当前专利权人地址： MI Kalamazoo
- 主分类号： A61K31/195
- IPC分类号： A61K31/195 ; A61K31/198 ; A61K31/215 ; A61P3/08 ; A61P3/10 ; C07C281/16 ; C07C281/18
摘要：
The present invention provides novel compounds of the formulae (I): AG--(CH.sub.2).sub.n --CO.sub.2 R.sup.1 and (II) or pharmacologically acceptable salts thereof, wherein AG is: a) N-aminoguanidine, b) N,N'-diaminoguanidine, or c) N,N',N"-triaminoguanidine; and n, R.sup.1 and R.sup.2 have the meanings given in the description as well as a new use for the compounds of formula (III) wherein R.sup.3 has the meanings given in the description for the treatment of non-insulin dependent diabetes mellitus (NIDDM).
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