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公开(公告)号：US09598441B2
公开(公告)日：2017-03-21
申请号：US14239881
申请日：2012-08-30
申请人： Arun K. Rishi , Scott D. Larsen
发明人： Arun K. Rishi , Scott D. Larsen
IPC分类号： C07D513/10 , A61K31/433 , C07D513/20
CPC分类号： C07D513/10 , A61K31/433 , C07D513/20
摘要： The invention provides compounds of formula I: and salts thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating cancer using compounds of formula I.
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2.发明申请PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开用于治疗神经损伤性疾病的PPAR-分散噻唑烷二酮和组合公开(公告)号：US20130053350A1
公开(公告)日：2013-02-28
申请号：US13515522
申请日：2010-12-15
IPC分类号： A61K31/426 , A61K31/675 , A61K31/427 , A61P25/00 , A61K31/444 , A61K31/4709 , A61P25/28 , A61K31/4439 , A61K31/522
摘要： The present invention relates to thiazolidinedione analogues and pharmaceutical compositions that are useful for treating and/or preventing neurodegenerative disorders.
摘要翻译： 本发明涉及可用于治疗和/或预防神经变性疾病的噻唑烷二酮类似物和药物组合物。
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3.发明申请PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF DIABETES MELLITUS AND OTHER METABOLIC DISEASES 审中-公开用于治疗糖尿病和其他代谢疾病的PPAR-分散噻唑烷二酮和组合公开(公告)号：US20120322728A1
公开(公告)日：2012-12-20
申请号：US13515549
申请日：2010-12-15
IPC分类号： A61K31/426 , A61K38/26 , A61K31/4985 , A61P3/10 , A61K31/513 , A61K31/427 , A61K31/675 , A61K31/4439 , A61K31/522
CPC分类号： A61K31/426 , A61K31/4439
摘要： The present invention relates to thiazolidinedione analogues and pharmaceutical compositions that are useful for treating and/or preventing diabetes mellitis, optionally in combination with a second treatment. Furthermore, the present invention also provides methods of inducing remission of the symptoms of diabetes mellitis in a patient comprising administering a thiazolidinedione analogue and a GLP-1 agonist.
摘要翻译： 本发明涉及可用于治疗和/或预防糖尿病的噻唑烷二酮类似物和药物组合物，任选地与第二种治疗组合。 此外，本发明还提供了在患者中诱导糖尿病性炎症症状缓解的方法，包括施用噻唑烷二酮类似物和GLP-1激动剂。
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4.发明申请PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES 有权用于治疗代谢性疾病的PPAR-分散的噻唑烷二酮公开(公告)号：US20120309975A1
公开(公告)日：2012-12-06
申请号：US13515508
申请日：2010-12-15
IPC分类号： C07D277/34 , C07F9/6539 , C07F9/6571 , C07D417/12
CPC分类号： C07D277/34 , C07D417/12
摘要： The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer's Disease).
摘要翻译： 本发明涉及可用于治疗和/或预防代谢性疾病（例如，糖尿病或神经变性疾病（例如阿尔茨海默氏病））的噻唑烷二酮类和其它药剂的新型盐。
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公开(公告)号：US06458788B1
公开(公告)日：2002-10-01
申请号：US09808902
申请日：2001-03-15
IPC分类号： A61K315377
CPC分类号： C07D405/06 , C07D237/28 , C07D413/06
摘要： Certain novel 4-hydroxycinnoline-3-carboxyamides. The compounds are particularly effective in the treatment or prevention of viral infections, particularly infections caused by herpes viruses including herpes simplex virus types 1 and 2, human herpes virus types 6, 7 and 8, varicello zoster virus, human cytomegalovirus or Epstein-Barr virus.
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公开(公告)号：US06410585B1
公开(公告)日：2002-06-25
申请号：US09265410
申请日：1999-03-10
申请人： Scott D. Larsen , Paul D. May , John E. Bleasdale , Charlotta Liljebris , Heinrich Josef Schostarez , Tjeerd Barf , Marianne Nilsson
发明人： Scott D. Larsen , Paul D. May , John E. Bleasdale , Charlotta Liljebris , Heinrich Josef Schostarez , Tjeerd Barf , Marianne Nilsson
IPC分类号： C07C23500
CPC分类号： C07C311/06 , A61K38/00 , C07C235/74 , C07C235/80 , C07C237/22 , C07C237/52 , C07C271/02 , C07C271/22 , C07C275/24 , C07C305/24 , C07C311/13 , C07C311/37 , C07C317/50 , C07C323/59 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2603/66 , C07C2603/70 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/13 , C07D295/215 , C07K5/06026 , C07K5/06034 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06104 , C07K5/06113 , C07K5/06139 , C07K5/06156
摘要： The present invention comprises small molecular weight, non-peptidic inhibitors of formulae I-VII of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).
摘要翻译： 本发明包括可用于治疗和/或预防非胰岛素依赖性糖尿病（NIDDM）的蛋白酪氨酸磷酸酶1（PTP1）的式I-VII的小分子量非肽抑制剂。
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公开(公告)号：US06353023B1
公开(公告)日：2002-03-05
申请号：US09138642
申请日：1998-08-24
申请人： Scott D. Larsen , Paul D. May , John E. Bleasdale , Charlotta Liljebris , Heinrich Josef Schostarez , Tjeerd Barf
发明人： Scott D. Larsen , Paul D. May , John E. Bleasdale , Charlotta Liljebris , Heinrich Josef Schostarez , Tjeerd Barf
IPC分类号： C07C23722
CPC分类号： C07D295/215 , A61K38/00 , C07C235/74 , C07C235/80 , C07C237/52 , C07C271/02 , C07C271/22 , C07C275/24 , C07C305/24 , C07C311/06 , C07C311/13 , C07C311/37 , C07C317/50 , C07C323/59 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2603/66 , C07C2603/70 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/13 , C07K5/06026 , C07K5/06034 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06104 , C07K5/06113 , C07K5/06156
摘要： The present invention comprises small molecular weight, non-peptidic inhibitors of formula I and II of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).
摘要翻译： 本发明包括可用于治疗和/或预防非胰岛素依赖性糖尿病（NIDDM）的蛋白酪氨酸磷酸酶1（PTP1）的分子量小的非肽抑制剂I和II。
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8.发明授权Aminoguanidine carboxylate lactams for the treatment of non-insulin-dependent diabetes mellitus 失效氨基胍羧酸内酰胺用于治疗非胰岛素依赖性糖尿病公开(公告)号：US06177453B1
公开(公告)日：2001-01-23
申请号：US09307137
申请日：1999-05-07
IPC分类号： A61P304
CPC分类号： B60G17/052 , B60G21/023 , B60G21/026 , B60G21/10 , B60G2202/21 , C07D233/88 , C07D253/06
摘要： The present invention provides for the treatment of non-insulin dependent diabetes mellitus or obesity comprising the systemic administration of a compound having the formula or a pharmacologically acceptable salt thereof, wherein each R is H or NH2, and with the proviso that at least one R group must be NH2.
摘要翻译： 本发明提供了治疗非胰岛素依赖性糖尿病或肥胖症，其包括全身给予具有其药理学上可接受的盐的化合物，其中每个R是H或NH 2，条件是至少一个R基团 必须是NH2。
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9.发明授权PPAR-sparing thiazolidinedione salts for the treatment of metabolic diseases 有权用于治疗代谢疾病的PPAR保留噻唑烷二酮盐公开(公告)号：US08912335B2
公开(公告)日：2014-12-16
申请号：US13515508
申请日：2010-12-15
IPC分类号： C07D417/12 , C07D277/34
CPC分类号： C07D277/34 , C07D417/12
摘要： The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer's Disease).
摘要翻译： 本发明涉及可用于治疗和/或预防代谢性疾病（例如，糖尿病或神经变性疾病（例如阿尔茨海默氏病））的噻唑烷二酮类和其它药剂的新型盐。
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公开(公告)号：US20130211095A1
公开(公告)日：2013-08-15
申请号：US13641898
申请日：2011-04-18
IPC分类号： C07D277/04
CPC分类号： C07D213/50 , C07D277/04 , C07D277/34
摘要： The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
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