发明授权
- 专利标题: Human chemokines, CK&bgr;4 and CK&bgr;10/MCP-4
- 专利标题(中): 人类趋化因子,CKbeta4和CKbeta10 / MCP-4
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申请号: US08613822申请日: 1996-02-23
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公开(公告)号: US06174995B1公开(公告)日: 2001-01-16
- 发明人: Haodong Li , Mark Adams , Solange Hanschke Lima , Ralph Alderson , Yuling Li , David Parmelee , John White , Edward Applebaum
- 申请人: Haodong Li , Mark Adams , Solange Hanschke Lima , Ralph Alderson , Yuling Li , David Parmelee , John White , Edward Applebaum
- 主分类号: C07K1452
- IPC分类号: C07K1452
摘要:
Human chemokine polypeptides and DNA/(RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
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