A collimator 100 for use in a radiation imaging system 10, and a method for making such collimators, are provided, wherein the collimator 100 is capable of collimating radiation in two orthogonal planes. The collimator in one embodiment includes a block 101 of radiation absorbing material having a plurality of focally aligned channels 102 extending therethrough; in a second embodiment, the collimator includes first and second collimation204, 212 sections having a respective first plurality of focally aligned plate sets 201 and a respective second plurality of focally aligned plate sets 203 disposed orthogonally to the first plurality of plate sets. The method for making the collimator includes generating a CAD drawing, generating from the CAD drawing one or more stereo-lithographic files, and using the stereo-lithographic files to control an electro-deposition machining machine which creates the channels in the block.