发明授权
US06177443B1 4,5,6,7-tetrahydro-thieno[3, 2-C]pyridine derivatives, their preparation and use
失效
4,5,6,7-四氢 - 噻吩并[3,2-C]吡啶衍生物,其制备和用途
- 专利标题: 4,5,6,7-tetrahydro-thieno[3, 2-C]pyridine derivatives, their preparation and use
- 专利标题(中): 4,5,6,7-四氢 - 噻吩并[3,2-C]吡啶衍生物,其制备和用途
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申请号: US09035464申请日: 1998-03-05
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公开(公告)号: US06177443B1公开(公告)日: 2001-01-23
- 发明人: Peter Madsen , Jane Marie Lundbeck , Niels Westergarrd , Lars Naerum , Annemarie Reinhardt Varming , Helle Demuth , Morten Heide
- 申请人: Peter Madsen , Jane Marie Lundbeck , Niels Westergarrd , Lars Naerum , Annemarie Reinhardt Varming , Helle Demuth , Morten Heide
- 优先权: DK0249/97 19970307; DK1365/97 19971127
- 主分类号: A61K3144
- IPC分类号: A61K3144
摘要:
The present invention relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and a compound of formula I wherein A together with the double bond of formula I is benzene or thiophene; R1 is optionally substituted C1-6 alkyl or optionally substituted aryl; R2 is optionally substituted C1-6-alkyl, optionally substituted aralkyl, or —COR3, wherein R3 is optionally substituted C1-6-alkyl, optionally substituted aralkyl, or optionally substituted aryl; R4 and R5 independently are hydrogen, halogen, perhalomethyl, optionally substituted C1-6-alkyl, hydroxy, optionally substituted C1-6-alkoxy, nitro, cyano, amino, optionally substituted mono- or optionally substituted di-C1-6-alkylamino, acylamino, C1-6-alkoxycarbonyl, carboxy or carbamoyl; n is 0, and m is 1, and methods of treating or preventing a disease of the endocrinologic system.