公开(公告)号：US06177443B1

公开(公告)日：2001-01-23

申请号：US09035464

申请日：1998-03-05

申请人： Peter Madsen ,  Jane Marie Lundbeck ,  Niels Westergarrd ,  Lars Naerum ,  Annemarie Reinhardt Varming ,  Helle Demuth ,  Morten Heide

发明人： Peter Madsen ,  Jane Marie Lundbeck ,  Niels Westergarrd ,  Lars Naerum ,  Annemarie Reinhardt Varming ,  Helle Demuth ,  Morten Heide

IPC分类号： A61K3144

CPC分类号： A61K31/4365 ,  A61K31/44 ,  A61K31/47

摘要： The present invention relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and a compound of formula I wherein A together with the double bond of formula I is benzene or thiophene; R1 is optionally substituted C1-6 alkyl or optionally substituted aryl; R2 is optionally substituted C1-6-alkyl, optionally substituted aralkyl, or —COR3, wherein R3 is optionally substituted C1-6-alkyl, optionally substituted aralkyl, or optionally substituted aryl; R4 and R5 independently are hydrogen, halogen, perhalomethyl, optionally substituted C1-6-alkyl, hydroxy, optionally substituted C1-6-alkoxy, nitro, cyano, amino, optionally substituted mono- or optionally substituted di-C1-6-alkylamino, acylamino, C1-6-alkoxycarbonyl, carboxy or carbamoyl; n is 0, and m is 1, and methods of treating or preventing a disease of the endocrinologic system.

摘要翻译： 本发明涉及包含药学上可接受的载体或稀释剂和式I化合物的药物组合物，其中A与式I的双键是苯或噻吩; R1是任选取代的C 1-6烷基或任选取代的芳基; R 2是任选取代的C 1-6 - 烷基，任选取代的芳烷基或-COR 3，其中R 3是任选取代的C 1-6 - 烷基，任选取代的芳烷基或任选取代的芳基; R 4和R 5独立地是氢，卤素，全卤甲基，任选取代的C 1-6 - 烷基，羟基，任选取代的C 1-6 - 烷氧基，硝基，氰基，氨基，任选取代的单 - 或任选取代的二-C 1-6烷基氨基， 酰基氨基，C 1-6 - 烷氧基羰基，羧基或氨基甲酰基; n为0，m为1，以及治疗或预防内分泌系统疾病的方法。