发明授权
- 专利标题： Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative
- 专利标题（中）： 通过施用芳基环己胺衍生物治疗神经变性疾病的方法
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申请号： US09370602申请日： 1999-08-09
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公开(公告)号： US06184236B2公开(公告)日： 2001-02-06
- 发明人: Alexander Alanine , Bernd Büttelmann , Marie-Paule Heitz Neidhart , Emmanuel Pinard , René Wyler
- 申请人： Alexander Alanine , Bernd Büttelmann , Marie-Paule Heitz Neidhart , Emmanuel Pinard , René Wyler
- 优先权： EP98115484 19980818
- 主分类号： A61K31445
- IPC分类号： A61K31445
摘要：
The present invention provides a method of treatment of a disease associated with neurodegeneration by administering a therapeutically effective amount of a compound of the general formula wherein Ar1 is phenyl, naphthyl or tetrahydronaphthyl, optionally substituted by hydroxy, lower alkoxy, nitro, amino or methanesulfonamide; Ar2 is phenyl, naphthyl or tetrahydronaphthyl, optionally substituted by lower alkyl or halogen; X is C, CH, C(OH) or N; Y is —CH2−, CH or O; Z —CH2—, —CH(CH3)— or —C(CH3)2—; R1 is hydrogen, lower alkyl or acetyl; A is C═O or —(CHR2)n—, wherein R2 is hydrogen, lower alkyl or hydroxy-lower alkyl; B is —(CH2)n—, O, —CH(OH)(CH2)n—, —CH(CH2OH)(CH2)n—, —(CH2)n CH(OH)— or —CH(CH2OH)—; - - - may be a bond; and n is 0-4, or pharmaceutically acceptable acid addition salts thereof.
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