发明授权
- 专利标题： Process for producing quinolone derivatives
- 专利标题（中）： 制备喹诺酮衍生物的方法
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申请号： US09420521申请日： 1999-10-18
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公开(公告)号： US06187926B1公开(公告)日： 2001-02-13
- 发明人: Tatsushi Osawa , Kazuo Kubo , Hideko Murooka , Tatsuo Nakajima
- 申请人： Tatsushi Osawa , Kazuo Kubo , Hideko Murooka , Tatsuo Nakajima
- 优先权： JP9-101220 19970418
- 主分类号： C07D215233
- IPC分类号： C07D215233
摘要：
The present invention relates to a process for producing a 4-quinolone derivative, comprising allowing an o-aminoacetophenone derivative to react with a formic acid in an aprotic solvent in the presence of a suitable base, and adding a protic solvent to the reaction mixture. This is a simple process for producing 4-quinolone derivatives, applicable to large-scale commercial production.
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