发明授权
- 专利标题: Benzimidazole compounds as bradykinin antagonists
- 专利标题(中): 苯并咪唑化合物作为缓激肽拮抗剂
-
申请号: US09425207申请日: 1999-10-22
-
公开(公告)号: US06194396B1公开(公告)日: 2001-02-27
- 发明人: Teruo Oku , Hiroshi Kayakiri , Shigeki Satoh , Yoshito Abe , Yuki Sawada , Takayuki Inoue , Hirokazu Tanaka
- 申请人: Teruo Oku , Hiroshi Kayakiri , Shigeki Satoh , Yoshito Abe , Yuki Sawada , Takayuki Inoue , Hirokazu Tanaka
- 优先权: JP6-182541 19940803; JP7-57427 19950316
- 主分类号: A61K314184
- IPC分类号: A61K314184
摘要:
This invention relates to a heterocyclic compound of the formula wherein a group of the formula: is a group of the formula X is O, S or N-R5, R1 is lower alkyl, etc., R5 is hydrogen, lower alkyl, etc., R2 is hydrogen, halogen, lower alkyl, etc., R3 is halogen, lower alkyl, etc., R4 is amino optionally having suitable substituent(s), and A is lower alkylene, and a salt thereof, to processes for preparation thereof, and to a pharmaceutical composition comprising the same for the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.