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    Hetero compound
    1.
    发明授权
    Hetero compound 有权
    杂环化合物

    公开(公告)号：US07951825B2

    公开(公告)日：2011-05-31

    申请号：US12696327

    申请日：2010-01-29

    Applicant: Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    Inventor： Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    IPC: C07D413/02 ,  C07D413/14 ,  C07D401/02 ,  C07D401/14 ,  A61K31/443

    CPC classification number: C07D413/04 ,  C07D417/04 ,  C07D471/04

    Abstract: To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.

    Abstract translation: 为了提供具有优异的S1P1激动剂活性的器官，骨髓或组织，自身免疫疾病等的移植中的预防和/或治疗剂的有效成分的有用化合物。 由于本发明的化合物具有S1P1激动剂活性，因此可用作治疗或预防由不利淋巴细胞浸润引起的疾病的活性成分，例如自体免疫疾病例如器官移植中的移植排斥反应 骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化症，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺病，哮喘，特应性皮炎 炎症性肠病，动脉粥样硬化，缺血再灌注损伤或炎性疾病，以及由细胞如癌症和白血病的异常生长或积累引起的疾病。

    Hetero compound
    2.
    发明授权
    Hetero compound 有权
    杂环化合物

    公开(公告)号：US07678820B2

    公开(公告)日：2010-03-16

    申请号：US12244102

    申请日：2008-10-02

    Applicant: Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    Inventor： Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    IPC: A61K31/4245 ,  C07D271/06

    CPC classification number: C07D413/04 ,  C07D417/04 ,  C07D471/04

    Abstract: To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity. Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.

    Abstract translation: 为了提供具有优异的S1P1激动剂活性的器官，骨髓或组织，自身免疫疾病等的移植中的预防和/或治疗剂的有效成分的有用化合物。 由于本发明的化合物具有S1P1激动剂活性，因此可用作治疗或预防由不利淋巴细胞浸润引起的疾病的活性成分，例如自体免疫疾病例如器官移植中的移植排斥反应 骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化症，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺病，哮喘，特应性皮炎 炎症性肠病，动脉粥样硬化，缺血再灌注损伤或炎性疾病，以及由细胞如癌症和白血病的异常生长或积累引起的疾病。

    Sulfonamide compounds and uses thereof as medicines
    4.
    发明授权
    Sulfonamide compounds and uses thereof as medicines 失效
    磺酰胺化合物及其作为药物的用途

    公开(公告)号：US06890934B2

    公开(公告)日：2005-05-10

    申请号：US10360806

    申请日：2003-02-10

    Applicant: Noriko Oku ,  Chikaka Oku ,  Tomohiro Oku ,  Hiroshi Kayakiri ,  Yoshito Abe ,  Hitoshi Hamashima ,  Hitoshi Sawada ,  Naoki Ishibashi ,  Hiroyuki Setoi ,  Noritsugu Yamasaki ,  Takafumi Imoto ,  Takahiro Hiramura

    Inventor： Teruo Oku

    IPC: A61P43/00 ,  C07D471/04 ,  A61K31/437

    CPC classification number: C07D471/04

    Abstract: The present invention relates to a sulfonamide compound of the formula (I): wherein each symbol is as defined in the specification, a salt thereof, and a pharmaceutical composition containing same. This compound can be an effective agent for the prophylaxis and treatment of the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy suppressing action.

    Abstract translation: 本发明涉及式（I）的磺酰胺化合物：其中每个符号如说明书中所定义，其盐和含有其的药物组合物。 该化合物可以是用于预防和治疗基于降血糖作用的可治疗疾病的有效试剂，以及基于cGMP-PDE抑制作用，平滑肌松弛作用，支气管扩张作用，血管舒张作用， 平滑肌细胞抑制作用和过敏抑制作用。

    Heterocyclic compounds as bradykinin antagonists
    5.
    发明授权
    Heterocyclic compounds as bradykinin antagonists 失效
    杂环化合物作为缓激肽拮抗剂

    公开(公告)号：US06344462B1

    公开(公告)日：2002-02-05

    申请号：US09604526

    申请日：2000-06-27

    Applicant: Teruo Oku ,  Hiroshi Kayakiri ,  Yoshito Abe ,  Yuki Sawada ,  Tsuyoshi Mizutani

    Inventor： Teruo Oku ,  Hiroshi Kayakiri ,  Yoshito Abe ,  Yuki Sawada ,  Tsuyoshi Mizutani

    IPC: A61K3144

    CPC classification number: C07D231/12 ,  C07D215/26 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D401/14 ,  C07D409/12 ,  C07D409/14 ,  C07D471/04

    Abstract: This invention relates to a compound of the formula: wherein A1 is lower alkylene, R1 is substituted quinolyl, etc., R2 is hydrogen, halogen or lower alkyl, R3 is halogen or lower alkyl, and R4 is a group of the formula: —Q—A2—R5, etc.,  in which R5 is amino, acylamino, etc., A2 is lower alkylene or a single bond, and Q is a group of the formula:  and pharmaceutically acceptable salts thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to methods of using the same therapeutically in the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.

    Abstract translation: 本发明涉及下式化合物：其中A 1为低级亚烷基，R 1为取代的喹啉基等，R 2为氢，卤素或低级烷基，R 3为卤素或低级烷基，R 4为下式基团：其中R 5为 氨基，酰氨基等，A2为低级亚烷基或单键，Q为下式的基团及其药学上可接受的盐，其制备方法，含有该化合物的药物组合物，以及使用 在预防和/或治疗缓激肽或其类似物介导的人或动物疾病方面相同。

    Image synthesizing apparatus and image pickup apparatus with a brightness adjusting processing
    10.
    发明授权
    Image synthesizing apparatus and image pickup apparatus with a brightness adjusting processing 有权
    具有亮度调整处理的图像合成装置和图像拾取装置

    公开(公告)号：US08026962B2

    公开(公告)日：2011-09-27

    申请号：US12397726

    申请日：2009-03-04

    Applicant: Yoshito Abe ,  Kazunori Kita

    Inventor： Yoshito Abe ,  Kazunori Kita

    IPC: H04N5/217

    CPC classification number: H04N5/243 ,  G06T5/002 ,  G06T5/009 ,  G06T5/40 ,  G06T5/50 ,  G06T2207/10016 ,  G06T2207/20221

    Abstract: Disclosed is an image synthesizer including an image frames memory which memorizes a plurality of image frames which are produced by continuously taking pictures of a subject, an image synthesizer which synthesizes a plurality of image frames to a summation image, an image brightness adjuster which adjusts brightness of the summation image by synthesizing the image frames with the image synthesizer, and a display which displays the summation image which is being synthesized by the image synthesizing means in the image brightness adjusting processing.

    Abstract translation: 公开了一种图像合成器，包括存储多个图像帧的图像帧存储器，所述图像帧存储器通过连续拍摄被摄体的图像，合成多个图像帧的图像合成器到和图像，调整亮度的图像亮度调节器 通过与图像合成器合成图像帧，以及在图像亮度调整处理中显示由图像合成装置合成的求和图像的显示。

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