发明授权
- 专利标题： Heterocyclic derivatives and pharmaceutical use thereof
- 专利标题（中）： 杂环衍生物及其药物用途
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申请号： US09506839申请日： 2000-02-18
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公开(公告)号： US06200988B1公开(公告)日： 2001-03-13
- 发明人: Shoji Kamiya , Hiroaki Shirahase , Hiroshi Matsui , Shohei Nakamura , Katsuo Wada
- 申请人： Shoji Kamiya , Hiroaki Shirahase , Hiroshi Matsui , Shohei Nakamura , Katsuo Wada
- 优先权： JP7-259082 19951005; JP8-058018 19960314; JP8-194331 19960724
- 主分类号： C07D21540
- IPC分类号： C07D21540
摘要：
A heterocyclic derivative of the formula (I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof exhibit superior ACAT inhibitory activity and lipoperoxidation inhibitory activity in mammals, and are useful as ACAT inhibitors and lipoperoxidation inhibitors. Specifically, they are useful for the prophylaxis and treatment of arteriosclerosis, hyperlipemia, arteriosclerosis in diabetes, and cerebrovascular and cardiovascular ischemic diseases.
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