发明授权
US06210961B1 Recombinant infectious bovine rhinotracheitis virus comprising foreign DNA inserted into a non-essential region of a infectious bovine rhinotracheitis virus genome
失效
重组感染性牛鼻气管炎病毒，其包含插入感染性牛鼻气管炎病毒基因组非必需区域的外来DNA
- 专利标题： Recombinant infectious bovine rhinotracheitis virus comprising foreign DNA inserted into a non-essential region of a infectious bovine rhinotracheitis virus genome
- 专利标题（中）： 重组感染性牛鼻气管炎病毒，其包含插入感染性牛鼻气管炎病毒基因组非必需区域的外来DNA
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申请号： US08912803申请日： 1997-08-18
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公开(公告)号： US06210961B1公开(公告)日： 2001-04-03
- 发明人: Mark D. Cochran , Meng-Fu Shih , William P. MacConnell , Richard D. Macdonald
- 申请人： Mark D. Cochran , Meng-Fu Shih , William P. MacConnell , Richard D. Macdonald
- 主分类号： C12N1586
- IPC分类号： C12N1586
摘要：
The present invention provides a hybrid, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the hybrid, nonprimate herpesvirus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus and at least one foreign DNA sequence. Also provided is an attenuated, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the attenuated, nonprimate herpesvirus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus, from which at least a portion of a repeat sequence has been deleted. Also provided are vaccines comprising the viruses of the invention and methods of immunizing animals against various disease.
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