发明授权
- 专利标题： Subtype-selective NMDA receptor ligands and the use thereof
- 专利标题（中）： 亚型选择性NMDA受体配体及其用途
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申请号： US09091592申请日： 1998-09-16
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公开(公告)号： US06218404B1公开(公告)日： 2001-04-17
- 发明人: Christopher F. Bigge , Gian Luca Araldi , Sui Xiong Cai , Anthony P. Guzikowski , Donald Lamunyon , Nancy F. Lan , Zhang-Lin Zhou , John F. W. Keana
- 申请人： Christopher F. Bigge , Gian Luca Araldi , Sui Xiong Cai , Anthony P. Guzikowski , Donald Lamunyon , Nancy F. Lan , Zhang-Lin Zhou , John F. W. Keana
- 主分类号： C07D21106
- IPC分类号： C07D21106
摘要：
The invention relates to subtype-selective NMDA receptor ligands and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neuro-degenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, Parkinson's disease, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.
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