发明授权
- 专利标题： Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
- 专利标题（中）： 用叶酸衍生的金属络合物用于诊断和治疗应用
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申请号： US09477072申请日： 2000-01-03
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公开(公告)号： US06221334B1公开(公告)日： 2001-04-24
- 发明人: Paul W. Wedeking , Ruth E. Wager , Thangavel Arunachalam , Kondareddiar Ramalingam , Karen E. Linder , Ramachandran S. Ranganathan , Adrian D. Nunn , Natarajan Raju , Michael F. Tweedle
- 申请人： Paul W. Wedeking , Ruth E. Wager , Thangavel Arunachalam , Kondareddiar Ramalingam , Karen E. Linder , Ramachandran S. Ranganathan , Adrian D. Nunn , Natarajan Raju , Michael F. Tweedle
- 主分类号： A61K5100
- IPC分类号： A61K5100
摘要：
Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the &agr;, &ggr;, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
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