-
公开(公告)号：US08216569B2
公开(公告)日：2012-07-10
申请号：US11980495
申请日：2007-10-31
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00 , C07K16/18 , C07K16/22
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
-
公开(公告)号：US20110229466A1
公开(公告)日：2011-09-22
申请号：US13096144
申请日：2011-04-28
IPC分类号： A61K39/395 , A61P27/02 , A61P27/06
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译： 公开了人VEGF-2抗体，抗体片段或其变体。 还提供了产生这种抗体的方法。 本发明涉及用于预防，治疗或改善疾病或病症的方法和组合物，包括向动物（优选人）施用有效量的一种或多种VEGF-2抗体或其片段或变体。
-
公开(公告)号：US07402312B2
公开(公告)日：2008-07-22
申请号：US10992196
申请日：2004-11-19
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , C07K14/475 , C07K16/22 , C07K2317/73 , C07K2317/92 , A61K2300/00
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention also relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译： 公开了人VEGF-2抗体，抗体片段或其变体。 还提供了产生这种抗体的方法。 本发明还涉及用于预防，治疗或改善疾病或病症的方法和组合物，其包括向动物，优选人类施用有效量的一种或多种VEGF-2抗体或其片段或变体。
-
公开(公告)号：US08206708B2
公开(公告)日：2012-06-26
申请号：US13096144
申请日：2011-04-28
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00 , C07K16/18 , C07K16/22
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译： 公开了人VEGF-2抗体，抗体片段或其变体。 还提供了产生这种抗体的方法。 本发明涉及用于预防，治疗或改善疾病或病症的方法和组合物，包括向动物（优选人）施用有效量的一种或多种VEGF-2抗体或其片段或变体。
-
5.发明授权Metal complexes derivatized with folate for use in diagnostic and therapeutic applications 失效用叶酸衍生的金属络合物用于诊断和治疗应用公开(公告)号：US07186397B2
公开(公告)日：2007-03-06
申请号：US09752867
申请日：2000-12-30
申请人： Paul W. Wedeking , Ruth E. Wager , Thangavel Arunachalam , Kondareddiar Ramalingam , Karen E. Linder , Ramachandran S. Ranganathan , Adrian D. Nunn , Natarajan Raju , Michael F. Tweedle
发明人： Paul W. Wedeking , Ruth E. Wager , Thangavel Arunachalam , Kondareddiar Ramalingam , Karen E. Linder , Ramachandran S. Ranganathan , Adrian D. Nunn , Natarajan Raju , Michael F. Tweedle
CPC分类号： A61K49/10 , A61K49/085 , A61K49/122 , A61K49/124 , A61K49/146 , A61K51/0459 , A61K51/0497
摘要： Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the α, γ, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
摘要翻译： 用于增强诊断或治疗剂的跨膜转运的复合物形式的诊断和治疗组合物及其使用方法。 复合物含有叶酸的叶酸受体结合类似物的α，γ或双异构体，被配体螯合的金属，在一个实施方案中，化学治疗剂。
-
公开(公告)号：US20090023224A1
公开(公告)日：2009-01-22
申请号：US11730696
申请日：2007-04-03
IPC分类号： G01N33/566 , C07K16/22 , C12N5/16
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译： 公开了人VEGF-2抗体，抗体片段或其变体。 还提供了产生这种抗体的方法。 本发明涉及用于预防，治疗或改善疾病或病症的方法和组合物，包括向动物（优选人）施用有效量的一种或多种VEGF-2抗体或其片段或变体。
-
公开(公告)号：US20080286288A1
公开(公告)日：2008-11-20
申请号：US11980495
申请日：2007-10-31
IPC分类号： A61K39/395 , C12N15/11 , C12N15/00 , C12N5/06 , A61P43/00 , G01N33/53 , C12P21/04 , C07K16/18
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译： 公开了人VEGF-2抗体，抗体片段或其变体。 还提供了产生这种抗体的方法。 本发明涉及用于预防，治疗或改善疾病或病症的方法和组合物，包括向动物（优选人）施用有效量的一种或多种VEGF-2抗体或其片段或变体。
-
公开(公告)号：US07208582B2
公开(公告)日：2007-04-24
申请号：US10120414
申请日：2002-04-12
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译： 公开了人VEGF-2抗体，抗体片段或其变体。 还提供了产生这种抗体的方法。 本发明涉及用于预防，治疗或改善疾病或病症的方法和组合物，包括向动物（优选人）施用有效量的一种或多种VEGF-2抗体或其片段或变体。
-
公开(公告)号：US06541249B2
公开(公告)日：2003-04-01
申请号：US09740789
申请日：2000-12-21
申请人： Ruth E. Wager , Maria Ourmanova
发明人： Ruth E. Wager , Maria Ourmanova
IPC分类号： A01N6300
CPC分类号： C12R1/91 , C07K14/52 , C12N5/0634 , C12N5/0669 , C12N2502/1394 , C12N2510/04
摘要： A method for the culture of hematopoietic cells and/or production of human cytokines using immortalized human stromal cell lines is provided. These immortalized stromal cell lines condition media such that the ability of the hematopoietic stem cells to self-replicate and/or differentiate is maintained by the media or the ability of the committed progenitors to expand and/or differentiate is maintained by the media. Further provided are irradiated and non-irradiated immortalized human stromal cells that synthesize cytokines, such as, IL-7, IL-8, IL-11, FLT3L, SCF, LIF, M-CSF, TGF-beta 1, GM-CSF, MIP-1alpha, G-CSF, and MCP-1.
摘要翻译： 提供了使用永生化人类基质细胞系培养造血细胞和/或产生人细胞因子的方法。 这些永生化的基质细胞系使得介质使得造血干细胞自我复制和/或分化的能力由培养基维持，或由定性祖细胞扩增和/或分化的能力由培养基维持。 进一步提供合成细胞因子如IL-7，IL-8，IL-11，FLT3L，SCF，LIF，M-CSF，TGF-β1，GM-CSF的照射和未照射的永生化人类基质细胞， MIP-1alpha，G-CSF和MCP-1。
-
公开(公告)号：US20120213777A1
公开(公告)日：2012-08-23
申请号：US13460217
申请日：2012-04-30
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译： 公开了人VEGF-2抗体，抗体片段或其变体。 还提供了产生这种抗体的方法。 本发明涉及用于预防，治疗或改善疾病或病症的方法和组合物，包括向动物（优选人）施用有效量的一种或多种VEGF-2抗体或其片段或变体。
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.056 秒)
