发明授权
- 专利标题： Pseudoceramides, and dermatologic external preparations containing the same
- 专利标题（中）： 假甲酰胺和含有它们的皮肤外用制剂
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申请号： US09308031申请日： 1999-05-10
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公开(公告)号： US06221371B1公开(公告)日： 2001-04-24
- 发明人: In-sub Baik , Jong-gi Lee , Byeong-deog Park , Yoon Kim , Myung-jin Lee
- 申请人： In-sub Baik , Jong-gi Lee , Byeong-deog Park , Yoon Kim , Myung-jin Lee
- 优先权： KR96-53207 19961111
- 主分类号： A61K600
- IPC分类号： A61K600
摘要：
The present invention relates to pseudoceramide derivatives represented by formula(I) or (II): R1—COCHR2CONR3R4 (I) R1—CH(OH)CHR2CONR3R4 (II) wherein, each of R1 and R2 represents linear or branched alkyl group or alkenyl group having 6˜22 carbon atoms; each of R3 and R4 represents hydrogen, methyl, ethyl, propyl, or linear or branched C2˜C6 alkyl group having one or more hydroxyl group(s), or monosaccharide, a process for preparing the same, and dermatologic external preparations containing the same. When the pseudoceramide derivatives according to the present invention are applied in an dermatologic external preparations the moisture-retaining property and resilience of skin and hair is enhanced such so that the derivatives are useful in protection of skin-aging. In addition, the derivatives are useful for inducing the formation of lipid layer on damaged skin and for preventing the inhibition of lipid synthesis.
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