发明授权
- 专利标题: Cell-specific contrast agent and gene delivery vehicles
- 专利标题(中): 细胞特异性造影剂和基因递送载体
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申请号: US08321552申请日: 1994-10-12
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公开(公告)号: US06232295B1公开(公告)日: 2001-05-15
- 发明人: Jon Faiz Kayyem , Thomas J. Meade , Scott E. Fraser
- 申请人: Jon Faiz Kayyem , Thomas J. Meade , Scott E. Fraser
- 主分类号: A61K4800
- IPC分类号: A61K4800
摘要:
A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and MRI contrast agents are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.
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