A quick disconnect spray nozzle assembly having a nozzle body for connection to a fluid supply source and a removable and replaceable spray tip. The spray tip carries an externally mounted, elongated, tubular seal and biasing member which has an asymmetrical design, including an enlarged cylindrical downstream end and a rounded upstream end, configured for effecting radial and axial sealing forces upon engagement with seal a seating cavity in the nozzle body. The spray tip further includes radial camming and locking lugs having planar camming, detent, and locking surfaces which cooperate with the nozzle body for drawing the spray tip into mounted engagement, with the elongated sealing member interposed therebetween, as an incident to quick turn rotation of the spray tip and without the necessity for manually forcing the spray tip against the seal and biasing member.