Invention Grant
US06248767B1 Formulation of sulfonamides for treatment of endothelin-mediated disorders
失效
用于治疗内皮素介导的疾病的磺酰胺的制剂
- Patent Title: Formulation of sulfonamides for treatment of endothelin-mediated disorders
- Patent Title (中): 用于治疗内皮素介导的疾病的磺酰胺的制剂
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Application No.: US08938444Application Date: 1997-09-26
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Publication No.: US06248767B1Publication Date: 2001-06-19
- Inventor: Natalie Blok , Chengde Wu , Patricia Woodard , Karin Keller , Timothy Kogan
- Applicant: Natalie Blok , Chengde Wu , Patricia Woodard , Karin Keller , Timothy Kogan
- Main IPC: A61K3142
- IPC: A61K3142

Abstract:
Formulations of pharmaceutically-acceptable salts of thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides using the formulations are provided. In particular, formulations of sodium salts of N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides and methods using these sulfonamide salts for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide salt are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamide salts or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.
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