发明授权
- 专利标题: Sustained release dosage form unit having latex coating and method of making the same
- 专利标题(中): 具有胶乳涂层的缓释剂型单元及其制备方法
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申请号: US09345915申请日: 1999-07-01
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公开(公告)号: US06251432B1公开(公告)日: 2001-06-26
- 发明人: Terrence B. Mazer , Joseph E. Walton , Barbara S. Arnholt , Monty L. Evans , Ronita K. Geckle , Daniel Hamilton , John J. Kropczynski, Jr. , Frank A. Murawski , Larry G. Tucker , Sherri A. Walker , Michael V. Walsh , Rhonda Cole Walsh
- 申请人: Terrence B. Mazer , Joseph E. Walton , Barbara S. Arnholt , Monty L. Evans , Ronita K. Geckle , Daniel Hamilton , John J. Kropczynski, Jr. , Frank A. Murawski , Larry G. Tucker , Sherri A. Walker , Michael V. Walsh , Rhonda Cole Walsh
- 主分类号: A61K930
- IPC分类号: A61K930
摘要:
Dosage form unit is provided to deliver one or more beneficial agents into a fluid, such as liquid enteral nutritional product. The dosage form unit includes a core containing at least one beneficial agent, preferably a marker dye, which is dispersible in the fluid. The core also contains a compatible binding agent to bind the beneficial agent together. Additional components of the core may include a plasticizer, a standard flow agent, a lubricant, additional tableting aids and at least one hydrophilic agent. A latex coating encases the core. The latex coating includes a mixture containing a substantially hydrophobic base material, preferably formed from an emulsion of cellulose acetate microspheres, which is capable of defining a matrix-type membrane, and at least one hydrophilic component being dispersible in the fluid. A dispersible beneficial agent is preferred as one of the hydrophilic components of the latex coating to allow immediate release of the beneficial agent therefrom. A method of making the dosage form unit also is provided.
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