公开(公告)号：US06251432B1

公开(公告)日：2001-06-26

申请号：US09345915

申请日：1999-07-01

申请人： Terrence B. Mazer ,  Joseph E. Walton ,  Barbara S. Arnholt ,  Monty L. Evans ,  Ronita K. Geckle ,  Daniel Hamilton ,  John J. Kropczynski, Jr. ,  Frank A. Murawski ,  Larry G. Tucker ,  Sherri A. Walker ,  Michael V. Walsh ,  Rhonda Cole Walsh

发明人： Terrence B. Mazer ,  Joseph E. Walton ,  Barbara S. Arnholt ,  Monty L. Evans ,  Ronita K. Geckle ,  Daniel Hamilton ,  John J. Kropczynski, Jr. ,  Frank A. Murawski ,  Larry G. Tucker ,  Sherri A. Walker ,  Michael V. Walsh ,  Rhonda Cole Walsh

IPC分类号： A61K930

CPC分类号： A61K9/286 ,  A61K9/2054 ,  A61K9/209 ,  A61K9/2866

摘要： Dosage form unit is provided to deliver one or more beneficial agents into a fluid, such as liquid enteral nutritional product. The dosage form unit includes a core containing at least one beneficial agent, preferably a marker dye, which is dispersible in the fluid. The core also contains a compatible binding agent to bind the beneficial agent together. Additional components of the core may include a plasticizer, a standard flow agent, a lubricant, additional tableting aids and at least one hydrophilic agent. A latex coating encases the core. The latex coating includes a mixture containing a substantially hydrophobic base material, preferably formed from an emulsion of cellulose acetate microspheres, which is capable of defining a matrix-type membrane, and at least one hydrophilic component being dispersible in the fluid. A dispersible beneficial agent is preferred as one of the hydrophilic components of the latex coating to allow immediate release of the beneficial agent therefrom. A method of making the dosage form unit also is provided.

摘要翻译： 提供剂量形式单元以将一种或多种有益剂递送到流体中，例如液体肠内营养产品。 剂型单元包括含有可分散在流体中的至少一种有益试剂，优选标记染料的核心。 核心还含有一种相容的结合剂以将有益剂结合在一起。 芯的另外的组分可以包括增塑剂，标准流动剂，润滑剂，另外的压片助剂和至少一种亲水剂。 乳胶涂层包裹核心。 胶乳涂层包括含有基本上疏水的基材的混合物，优选由乙酸纤维素微球的乳液形成，其能够限定基质型膜，以及至少一种可分散在流体中的亲水组分。 作为胶乳涂料的亲水组分之一，优选可分散的有益剂，以便立即从其中释放有益剂。 还提供了制备剂型单元的方法。

公开(公告)号：US06620434B2

公开(公告)日：2003-09-16

申请号：US09852364

申请日：2001-05-10

申请人： Terrence B. Mazer ,  Joseph E. Walton ,  Barbara S. Arnholt ,  Monty L. Evans ,  Ronita K. Geckle ,  Daniel Hamilton ,  John J. Kropczynski, Jr. ,  Frank A. Murawski ,  Larry G. Tucker ,  Sherri A. Walker ,  Michael V. Walsh ,  Rhonda Cole Walsh

发明人： Terrence B. Mazer ,  Joseph E. Walton ,  Barbara S. Arnholt ,  Monty L. Evans ,  Ronita K. Geckle ,  Daniel Hamilton ,  John J. Kropczynski, Jr. ,  Frank A. Murawski ,  Larry G. Tucker ,  Sherri A. Walker ,  Michael V. Walsh ,  Rhonda Cole Walsh

IPC分类号： A61K936

CPC分类号： A61K9/286 ,  A61K9/2054 ,  A61K9/209 ,  A61K9/2866

摘要： Dosage form unit is provided to deliver one or more beneficial agents into a fluid, such as liquid enteral nutritional product. The dosage form unit includes a core containing at least one beneficial agent, preferably a marker dye, which is dispersible in the fluid. The core also contains a compatible binding agent to bind the beneficial agent together. Additional components of the core may include a plasticizer, a standard flow agent, a lubricant, additional tableting aids and at least one hydrophilic agent. A latex coating encases the core. The latex coating includes a mixture containing a substantially hydrophobic base material, preferably formed from an emulsion of cellulose acetate microspheres, which is capable of defining a matrix-type membrane, and at least one hydrophilic component being dispersible in the fluid. A dispersible beneficial agent is preferred as one of the hydrophilic components of the latex coating to allow immediate release of the beneficial agent therefrom. A method of making the dosage form unit also is provided.

摘要翻译： 提供剂量形式单元以将一种或多种有益剂递送到流体中，例如液体肠内营养产品。 剂型单元包括含有可分散在流体中的至少一种有益试剂，优选标记染料的核心。 核心还含有一种相容的结合剂以将有益剂结合在一起。 芯的另外的组分可以包括增塑剂，标准流动剂，润滑剂，另外的压片助剂和至少一种亲水剂。 乳胶涂层包裹核心。 胶乳涂层包括含有基本上疏水的基材的混合物，优选由乙酸纤维素微球的乳液形成，其能够限定基质型膜，以及至少一种可分散在流体中的亲水组分。 作为胶乳涂料的亲水组分之一，优选可分散的有益剂，以便立即从其中释放有益剂。 还提供了制备剂型单元的方法。

公开(公告)号：US06277092B1

公开(公告)日：2001-08-21

申请号：US09032072

申请日：1998-02-27

申请人： Rhonda L. Cole ,  Ronita K. Geckle ,  Terrence B. Mazer ,  Frank A. Murawski ,  Carl J. Piontek ,  Gregory James Stephens ,  Joseph E. Walton

发明人： Rhonda L. Cole ,  Ronita K. Geckle ,  Terrence B. Mazer ,  Frank A. Murawski ,  Carl J. Piontek ,  Gregory James Stephens ,  Joseph E. Walton

IPC分类号： A61M3700

CPC分类号： A61M5/007 ,  A61J15/00 ,  A61J15/0026 ,  A61J15/0069 ,  A61M5/1407 ,  A61M5/1409 ,  A61M31/002

摘要： An apparatus for modifying a liquid enteral nutritional product. The apparatus includes a chamber having an inlet and an outlet. The inlet of the chamber is constructed to be fluidly connected to a supply container containing a liquid enteral nutritional. The chamber defines an interior space. The apparatus further includes a retainer disposed in the interior space defined by the chamber. The retainer is constructed to receive one or more dosage form units of beneficial agent therein. The apparatus further includes at least one dosage form unit of beneficial agent retained by the retainer.

摘要翻译： 一种用于改变液体肠内营养产品的装置。 该装置包括具有入口和出口的室。 腔室的入口被构造成流体连接到容纳液体肠内营养的供应容器。 室定义了一个内部空间。 该装置还包括设置在由腔限定的内部空间中的保持器。 保持器构造成在其中接收一种或多种有益剂的剂型单元。 该装置还包括由保持器保留的有益剂的至少一个剂型单元。