Alternative G-coupled receptors associated with retroviral entry into cells, methods of identifying the same, and diagnostic and therapeutic uses thereof

发明授权

US06251582B1 Alternative G-coupled receptors associated with retroviral entry into cells, methods of identifying the same, and diagnostic and therapeutic uses thereof 失效

标题翻译：与逆转录病毒进入细胞相关的替代G-偶联受体，鉴定其的方法及其诊断和治疗用途

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专利标题： Alternative G-coupled receptors associated with retroviral entry into cells, methods of identifying the same, and diagnostic and therapeutic uses thereof
专利标题（中）： 与逆转录病毒进入细胞相关的替代G-偶联受体，鉴定其的方法及其诊断和治疗用途
申请号： US09116498

申请日： 1998-07-16
公开(公告)号： US06251582B1

公开(公告)日： 2001-06-26
发明人: Dan R. Littman , Hongkui Deng , Derya Unutmaz , Vineet N. Kewalramani
申请人： Dan R. Littman , Hongkui Deng , Derya Unutmaz , Vineet N. Kewalramani
主分类号： C12Q170
IPC分类号： C12Q170

Alternative G-coupled receptors associated with retroviral entry into cells, methods of identifying the same, and diagnostic and therapeutic uses thereof

摘要：

The present invention provides two new HIV/SIV translocation promoting agents, Bonzo and BOB. The present invention also provides the amino acid and DNA sequences of human, African green monkey, and pigtail macaque of the receptor protein Bonzo. Mammalian cells transfected with Bonzo and/or BOB and human CD4 as well as antibodies to the receptor Bonzo are also included. Furthermore, a method of identifying other such translocation promoting agents is also disclosed. Diagnostic and therapeutic uses of the translocation promoting agents of the present invention are also provided.

摘要（中）：

本发明提供两种新的HIV / SIV易位促进剂Bonzo和BOB。本发明还提供了受体蛋白质Bonzo的人，非洲绿猴和猪尾猕猴的氨基酸和DNA序列。还包括用Bonzo和/或BOB和人CD4转染的哺乳动物细胞以及受体Bonzo的抗体。此外，还公开了鉴定其他这种易位促进剂的方法。还提供了本发明的易位促进剂的诊断和治疗用途。

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