发明授权
US06251620B1 Three dimensional structure of a ZAP tyrosine protein kinase fragment and modeling methods
失效
ZAP酪氨酸蛋白激酶片段的三维结构和建模方法
- 专利标题： Three dimensional structure of a ZAP tyrosine protein kinase fragment and modeling methods
- 专利标题（中）： ZAP酪氨酸蛋白激酶片段的三维结构和建模方法
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申请号： US08975040申请日： 1997-11-18
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公开(公告)号： US06251620B1公开(公告)日： 2001-06-26
- 发明人: Marcos H. Hatada , Xiaode Lu , Ellen R. Laird , Jennifer L. Karas , Mark J. Zoller , Dennis A. Holt
- 申请人： Marcos H. Hatada , Xiaode Lu , Ellen R. Laird , Jennifer L. Karas , Mark J. Zoller , Dennis A. Holt
- 主分类号： C12Q148
- IPC分类号： C12Q148
摘要：
The invention relates to human ZAP-70, and in particular, to the region of ZAP-70 containing the tandem Src homology-2 (“SH2”) domains, to crystalline forms thereof, liganded or unliganded, which are particularly useful for the determination of the three-dimensional structure of the protein. The three dimensional structure of the tandem SH2 region of ZAP provides information useful for the design of pharmaceutical compositions which inhibit the biological function of ZAP and other members of the ZAP family of SH2 domain-containing proteins, particularly those biological functions mediated by molecular interactions involving one or both SH2 domains.
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