发明授权
US06258529B1 PCR amplification of rearranged genomic variable regions of immunoglobulin genes
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免疫球蛋白基因重排基因组可变区的PCR扩增
- 专利标题： PCR amplification of rearranged genomic variable regions of immunoglobulin genes
- 专利标题（中）： 免疫球蛋白基因重排基因组可变区的PCR扩增
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申请号： US08348548申请日： 1994-12-01
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公开(公告)号： US06258529B1公开(公告)日： 2001-07-10
- 发明人: José Berdoz , Jean-Pierre Kraehenbuhl
- 申请人： José Berdoz , Jean-Pierre Kraehenbuhl
- 主分类号： C12Q168
- IPC分类号： C12Q168
摘要：
The invention features methods for isolating immunoglobulin variable region genes, and the use of these genes in the production of chimeric and isotype switched antibodies. The invention also features substantially pure DNA encoding a variable region of the antibody produced by hybridoma cell line HNK-20, and chimeric antibodies containing this variable region.
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