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公开(公告)号：US20060257415A1
公开(公告)日：2006-11-16
申请号：US10526271
申请日：2003-09-03
CPC分类号： A61K39/39 , A61K2039/55516 , A61K2039/55544
摘要： A method is provided for inducing the adaptive immune response of a patient to an antigen comprising administering to the patient an effective amount of a flagellin protein or peptide fragment thereof to induce an adaptive immune response to said antigen.
摘要翻译： 提供了一种用于诱导患者对抗原的适应性免疫应答的方法，包括向患者施用有效量的鞭毛蛋白或其肽片段以诱导对所述抗原的适应性免疫应答。
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2.发明授权Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response 失效羟基磷灰石 - 抗原缀合物和产生多抗Ig免疫应答的方法公开(公告)号：US06541000B1
公开(公告)日：2003-04-01
申请号：US09008353
申请日：1998-01-16
IPC分类号： A61K3900
CPC分类号： A61K39/39 , A61K47/52 , A61K2039/541 , A61K2039/55505 , Y02A50/472
摘要： A method for generating antigen-sensitized Ig-A-producing lymphoblasts in a mammal, using an immunogen comprising an antigen or antigen mixture in association with hydroxylated calcium phosphate (hydroxy apatite) is administered to a mucosal surface of the mammal.
摘要翻译： 使用包含与羟基化磷酸钙（羟基磷灰石）结合的抗原或抗原混合物的免疫原在哺乳动物中产生抗原敏化的产生IgA的淋巴母细胞的方法施用于哺乳动物的粘膜表面。
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3.发明授权Immunogenic polypeptides that mimic a surface polysaccharide antigen of a pathogenic microorganism, method for obtaining the same, and their use in vaccine compositions 失效模拟病原微生物的表面多糖抗原的免疫原性多肽，其获得方法及其在疫苗组合物中的应用公开(公告)号：US06528061B1
公开(公告)日：2003-03-04
申请号：US09144280
申请日：1998-08-31
申请人： Armelle Phalipon , Philippe Sansonetti , Franco Felici , Riccardo Cortese , Jean Pierre Kraehenbuhl
发明人： Armelle Phalipon , Philippe Sansonetti , Franco Felici , Riccardo Cortese , Jean Pierre Kraehenbuhl
IPC分类号： A01N6300
CPC分类号： C12Q1/025 , A61K39/00 , A61K2039/525 , C07K14/25 , C07K16/1228 , C07K2317/34 , G01N33/56911 , G01N33/56983 , G01N2333/25 , Y02A50/476
摘要： A purified immunogenic polypeptide comprises an epitope unit recognized by a protective monoclonal antibody having a high affinity and a high specificity for a surface polysaccharide of a pathogenic microorganism of bacterial, viral, or fungal origin. The polypeptide is capable of inducing an immune response in vivo against the pathogenic microorganism. The immune response confers protection in mice against challenge with the virulent microorganisms.
摘要翻译： 纯化的免疫原性多肽包含由对细菌，病毒或真菌来源的病原微生物的表面多糖具有高亲和力和高特异性的保护性单克隆抗体识别的表位单元。 该多肽能够在体内诱导针对病原微生物的免疫应答。 免疫应答赋予小鼠免受有毒微生物攻击的保护作用。
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公开(公告)号：US06290962B1
公开(公告)日：2001-09-18
申请号：US08200346
申请日：1994-02-23
申请人： Pierre Michetti , Iréne Corthésy-Theulaz , André Blum , Catherine Davin , Rainier Haas , Jean-Pierre Kraehenbuhl , Emilia Saraga
发明人： Pierre Michetti , Iréne Corthésy-Theulaz , André Blum , Catherine Davin , Rainier Haas , Jean-Pierre Kraehenbuhl , Emilia Saraga
IPC分类号： A61K3900
CPC分类号： A61K39/105 , A61K39/00 , A61K2039/541 , A61K2039/542 , A61K2039/55505 , A61K2039/55544 , A61K2039/6037 , C12N9/80 , Y02A50/466 , Y02A50/472 , Y02A50/476 , Y02A50/484
摘要： Method of eliciting in a mammalian host a protective immune response to Helicobacter infection and treatment of Helicobacter infection by administering to the host an immunogenically effective amount of a Helicobacter urease or urease subunits as antigen. Vaccine compositions are also provided.
摘要翻译： 在哺乳动物宿主中引发对幽门螺杆菌感染的保护性免疫应答和通过向宿主施用免疫原性有效量的幽门螺杆菌脲酶或脲酶亚基作为抗原来治疗幽门螺杆菌感染的方法。 还提供了疫苗组合物。
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5.发明授权PCR amplification of rearranged genomic variable regions of immunoglobulin genes 失效免疫球蛋白基因重排基因组可变区的PCR扩增公开(公告)号：US06258529B1
公开(公告)日：2001-07-10
申请号：US08348548
申请日：1994-12-01
IPC分类号： C12Q168
CPC分类号： C12Q1/6876 , C07K16/00 , C07K16/1027 , C12Q2600/156 , C12Q2600/158
摘要： The invention features methods for isolating immunoglobulin variable region genes, and the use of these genes in the production of chimeric and isotype switched antibodies. The invention also features substantially pure DNA encoding a variable region of the antibody produced by hybridoma cell line HNK-20, and chimeric antibodies containing this variable region.
摘要翻译： 本发明的特征在于分离免疫球蛋白可变区基因的方法，以及这些基因在嵌合和同种型转换抗体的产生中的用途。 本发明还具有编码由杂交瘤细胞系HNK-20产生的抗体的可变区的基本上纯的DNA，以及含有该可变区的嵌合抗体。
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公开(公告)号：US06251406B1
公开(公告)日：2001-06-26
申请号：US09413807
申请日：1999-10-07
IPC分类号： A61K39112
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , C07K2319/00 , C12N15/74 , C12N2710/20022 , C12N2710/20023 , Y02A50/476 , Y02A50/484 , Y10S977/804 , Y10S977/904 , Y10S977/917
摘要： This application relates to the use of attenuated prokaryotic miccrooganism strains (such as Salmonella) expressing nucleic acid encoding HPV proteins as vaccines against HPV infection and he associated increased risk of cancer. In particular, the work shows that it is possible to assemble VLPs in a prokaryotic organism and that nasal immunization of mice with the strains HPV-specific conformationally dependent and neutralizing antibodies in serum and genital secretions. The experiments described herein show that it is also possible to assemble chimeric VLPs of a HPV including a fusion partner and that tumor protection can be induced.
摘要翻译： 本申请涉及使用表达编码HPV蛋白的核酸的减毒原核微生态菌株（如沙门氏菌）作为HPV感染疫苗，并且与癌症风险增加有关。 特别是，这项工作表明，有可能在原核生物体中组装VLP，并且可以在血清和生殖道分泌物中对具有HPV特异性构象依赖性和中和抗体的菌株进行鼻腔免疫。 本文描述的实验表明，还可以组装包含融合伴侣的HPV的嵌合VLP并且可以诱导肿瘤保护。
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公开(公告)号：US06458368B1
公开(公告)日：2002-10-01
申请号：US09288861
申请日：1999-04-09
IPC分类号： A61K39112
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , C07K2319/00 , C12N15/74 , C12N2710/20022 , C12N2710/20023 , Y02A50/476 , Y02A50/484 , Y10S977/804 , Y10S977/904 , Y10S977/917
摘要： Attenuated strain of a prokaryotic microorganism, being an attenuated strain of Salmonella suitable for use in a live vaccine for administration to a human or animal, in which the microorganism is transformed with nucleic acid encoding Human papilloma virus 16 L1 major capsid protein. The protein assembles in the microorganism to form virus-like particles (VLPs) that are capable of illiciting an immune response sufficient to produce neutralizing antibodies in serum and genital secretions specific for Human papilloma 16 infection when the microorganism is administered to the human or animal body.
摘要翻译： 原核微生物的减毒菌株是适合用于给人或动物施用的活疫苗的沙门氏菌的减毒菌株，其中用编码人乳头瘤病毒16 L1主要衣壳蛋白的核酸转化微生物。 蛋白质组装在微生物中以形成病毒样颗粒（VLP），其能够在将微生物施用于人或动物体时，能够使足以产生针对人乳头状瘤16感染的血清和生殖分泌物中产生中和抗体的免疫应答 。
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公开(公告)号：US5972336A
公开(公告)日：1999-10-26
申请号：US85938
申请日：1993-07-06
申请人： Pierre Michetti , Andre Blum , Catherine Davin , Rainer Haas , Irene Corthesy-Theulaz , Jean-Pierre Kraehenbuhl , Emilia Saraga
发明人： Pierre Michetti , Andre Blum , Catherine Davin , Rainer Haas , Irene Corthesy-Theulaz , Jean-Pierre Kraehenbuhl , Emilia Saraga
IPC分类号： G01N33/569 , A61K38/46 , A61K39/00 , A61K39/02 , A61K39/106 , A61K39/108 , A61K39/39 , A61K39/395 , A61P31/04 , A61P37/00 , C07K14/195 , C07K14/37 , C07K14/41 , C07K16/00 , C07K16/40 , C07K19/00 , C12N9/80 , C12N15/09 , C12N15/55 , C12R1/645 , G01N33/573 , A61K9/127 , A61K31/535 , A61K38/00
CPC分类号： C12N9/80 , A61K2039/541 , A61K2039/55505 , A61K2039/6037 , A61K39/00
摘要： Method of eliciting in a mammalian host a protective immune response to Helicobacter infection by administering to the host an immunogenically effective amount of a Helicobacter urease or urease subunits as antigen. Vaccine compositions are also provided.
摘要翻译： 通过向宿主施用免疫原性有效量的作为抗原的尿素酶或脲酶亚基，在哺乳动物宿主中引发对幽门螺杆菌感染的保护性免疫应答的方法。 还提供了疫苗组合物。
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公开(公告)号：US5443832A
公开(公告)日：1995-08-22
申请号：US510154
申请日：1990-04-16
IPC分类号： A61K39/00 , A61K9/00 , A61K9/51 , A61K33/42 , A61K39/12 , A61K39/385 , A61K39/39 , A61K47/04 , A61K47/48 , A61K39/02
CPC分类号： A61K47/48015 , A61K39/39 , A61K2039/541 , A61K2039/55505
摘要： A method for generating antigen-sensitized Ig-A-producing lymphoblasts in a mammal, using an immunogen comprising an antigen or antigen mixture in association with hydroxylated calcium phosphate (hydroxy apatite) is administered to a mucosal surface of the mammal.
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