发明授权
- 专利标题: Aminopyridine-containing thiourea inhibitors of herpes viruses
- 专利标题(中): 含有氨基吡啶的疱疹病毒的硫脲抑制剂
-
申请号: US09444896申请日: 1999-11-22
-
公开(公告)号: US06262090B1公开(公告)日: 2001-07-17
- 发明人: Jonathan Bloom , Martin DiGrandi , Russell Dushin , Stanley Lang , Bryan O'Hara
- 申请人: Jonathan Bloom , Martin DiGrandi , Russell Dushin , Stanley Lang , Bryan O'Hara
- 主分类号: A61K3144
- IPC分类号: A61K3144
摘要:
Compounds of the formula wherein A is heteroaryl; R9-R12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R9 and R10 or R11 and R12 may be taken together to form aryl of 5 to 7 carbon atoms; W is O, NR6, or is absent; G is aryl or heteroaryl; and X is a bond X is a bond, —NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; and J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; or a pharmaceutical acceptable salt thereof, useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.
信息查询