公开(公告)号：US06555561B2

公开(公告)日：2003-04-29

申请号：US10099695

申请日：2002-03-15

申请人： Jonathan Bloom ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Bryan O'Hara

发明人： Jonathan Bloom ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Bryan O'Hara

IPC分类号： A61K3144

CPC分类号： C07D213/75 ,  C07D213/81 ,  C07D405/12 ,  C07D417/12

摘要： This invention provides compounds of formula I having the structure Wherein substitutions at X, G, R1, R2, R3, R4, R5 are set forth in the specification.

摘要翻译： 本发明提供具有在X，G，R 1，R 2，R 3，R 4，R 5中取代的结构的式I化合物。

公开(公告)号：US06407123B1

公开(公告)日：2002-06-18

申请号：US09670180

申请日：2000-09-26

申请人： Jonathan Bloom ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Bryan O'Hara

发明人： Jonathan Bloom ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Bryan O'Hara

IPC分类号： A61K31443

CPC分类号： C07D213/75 ,  C07D213/81 ,  C07D405/12 ,  C07D417/12

摘要： Compounds of the formula wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, —CN, —NO2, —CO2R6, —COR6, —OR6, —SR6, —SOR6, —SO2R6, —CONR7R8, —NR6N(R7R8), —N(R7R8) or W—Y—(CH2)n—Z ; or R2 and R3 or R3 and R4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; A is heteroaryl.

摘要翻译： 式R 1 -R 5的化合物独立地选自氢，1至6个碳原子的烷基，2至6个碳原子的链烯基，2至6个碳原子的炔基，1至6个碳原子的全卤代烷基，3至10个碳原子的环烷基 原子，3至10个碳成员的杂环烷基，芳基，杂芳基，卤素，-CN，-NO 2，-CO 2 R 6，-COR 6，-OR 6，-SR 6，-SOR 6，-SO 2 R 6，-CONR 7 R 8，-NR 6 N（R 7 R 8） N（R 7 R 8）或WY-（CH 2）n Z; 或R2和R3或R3和R4一起形成3至7元杂环烷基或3至7元杂芳基; R6和R7独立地为氢，1至6个碳原子的烷基，1至6个碳原子的全卤代烷基或芳基 ; R 8为氢，1至6个碳原子的烷基，1至6个碳原子的全卤烷基，3至10个碳原子的环烷基，3至10个成员的杂环烷基，芳基或杂芳基，或R 7和R 8一起可以形成3 至7元杂环烷基; A为杂芳基。

公开(公告)号：US06271236B1

公开(公告)日：2001-08-07

申请号：US09669943

申请日：2000-09-26

申请人： Jonathan Bloom ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Bryan O'Hara

发明人： Jonathan Bloom ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Bryan O'Hara

IPC分类号： C07D40102

CPC分类号： C07D213/75 ,  C07D213/81 ,  C07D405/12 ,  C07D417/12

摘要： Compounds of the formula wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, —CN, —NO2, —CO2R6, —COR6, —OR6, —SR6, —SOR6, —SO2R6, —CONR7R8, —NR6N(R7R8), —N(R7R8) or W—Y—(CH2)n—Z; or R2 and R3 or R3 and R4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; A is heteroaryl.

摘要翻译： 式R 1 -R 5的化合物独立地选自氢，1至6个碳原子的烷基，2至6个碳原子的链烯基，2至6个碳原子的炔基，1至6个碳原子的全卤代烷基，3至10个碳原子的环烷基 原子，3至10个碳成员的杂环烷基，芳基，杂芳基，卤素，-CN，-NO 2，-CO 2 R 6，-COR 6，-OR 6，-SR 6，-SOR 6，-SO 2 R 6，-CONR 7 R 8，-NR 6 N（R 7 R 8） N（R 7 R 8）或WY-（CH 2）n Z; 或R2和R3或R3和R4一起形成3至7元杂环烷基或3至7元杂芳基; R6和R7独立地为氢，1至6个碳原子的烷基，1至6个碳原子的全卤代烷基或芳基 ; R 8为氢，1至6个碳原子的烷基，1至6个碳原子的全卤烷基，3至10个碳原子的环烷基，3至10个成员的杂环烷基，芳基或杂芳基，或R 7和R 8一起可以形成3 至7元杂环烷基; A为杂芳基。

公开(公告)号：US06262082B1

公开(公告)日：2001-07-17

申请号：US09669483

申请日：2000-09-25

申请人： Jonathan Bloom ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Bryan O'Hara

发明人： Jonathan Bloom ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Bryan O'Hara

IPC分类号： C07D40112

CPC分类号： C07D213/75 ,  C07D213/81 ,  C07D405/12 ,  C07D417/12

摘要： Compounds of the formula wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, —CN, —NO2, —CO2R6, —COR6, —OR6, —SR6, —SOR6, —SO2R6, —CONR7R8, —NR6N(R7R8), —N(R7R8) or W—Y—(CH2)n—Z; or R2 and R3 or R3 and R4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; A is heteroaryl.

摘要翻译： 式R 1 -R 5的化合物独立地选自氢，1至6个碳原子的烷基，2至6个碳原子的链烯基，2至6个碳原子的炔基，1至6个碳原子的全卤代烷基，3至10个碳原子的环烷基 原子，3至10个碳成员的杂环烷基，芳基，杂芳基，卤素，-CN，-NO 2，-CO 2 R 6，-COR 6，-OR 6，-SR 6，-SOR 6，-SO 2 R 6，-CONR 7 R 8，-NR 6 N（R 7 R 8） N（R 7 R 8）或WY-（CH 2）n Z; 或R2和R3或R3和R4一起形成3至7元杂环烷基或3至7元杂芳基; R6和R7独立地为氢，1至6个碳原子的烷基，1至6个碳原子的全卤代烷基或芳基 ; R 8为氢，1至6个碳原子的烷基，1至6个碳原子的全卤烷基，3至10个碳原子的环烷基，3至10个成员的杂环烷基，芳基或杂芳基，或R 7和R 8一起可以形成3 至7元杂环烷基; A为杂芳基。

公开(公告)号：US06255349B1

公开(公告)日：2001-07-03

申请号：US09444734

申请日：1999-11-22

申请人： Jonathan Bloom ,  Kevin Curran ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Emily Norton ,  Adma Ross ,  Bryan O'Hara

发明人： Jonathan Bloom ,  Kevin Curran ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Emily Norton ,  Adma Ross ,  Bryan O'Hara

IPC分类号： A61K3117

CPC分类号： C07D211/96 ,  C07C335/20

摘要： Compounds having the formula:  wherein  R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, —CN, —NO2, —CO2R6, —COR6, —OR6, —SR6, —SOR6, —SO2R6, —CONR7R8, —NR6N(R7R8), —N(R7R8) or W—Y—(CH2)n—Z provided that at least one of R1-R5 is not hydrogen; or R2 and R3or R3 and R4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl;  R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl;  R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or  R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl;  W is O, NR6, or is absent;  Y is —(CO)— or —(CO2)—, or is absent;  Z is alkyl of 1 to 4 carbon atoms, —CN, —CO2R6, COR6, —CONR7R8, —OCOR6, —NR6COR7, —OCONR6, —OR6, —SR6, —SOR6, —SO2R6, SR6N(R7R8), —N(R7R8) or phenyl;  G is aryl or fused bicyclic heteroaryl;  X is a bond, —NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J;  J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and  n is an integer from 1 to 6; or a pharmaceutically acceptable salt thereof, useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

公开(公告)号：US08831208B2

公开(公告)日：2014-09-09

申请号：US13242695

申请日：2011-09-23

申请人： David Suendermann ,  Jackson Liscombe ,  Jonathan Bloom ,  Grace Li ,  Roberto Pieraccini

发明人： David Suendermann ,  Jackson Liscombe ,  Jonathan Bloom ,  Grace Li ,  Roberto Pieraccini

IPC分类号： H04M3/00

CPC分类号： H04M3/4936 ,  H04M3/5166 ,  H04M2201/39 ,  H04M2201/40 ,  H04M2203/355

摘要： A dialog manager for a spoken dialog system. A decision module selects a path from a plurality of alternative paths for a given call, wherein each path implements one of a plurality of strategies for a call flow. A weighting module weights the path selection decision and is connected to a probability estimator for estimating the probability value that a given one of the plurality of paths is the best-performing path.

摘要翻译： 一个口语对话系统的对话管理器。 决策模块从给定呼叫的多个替代路径中选择路径，其中每个路径实现呼叫流的多个策略之一。 加权模块对路径选择决定进行加权，并且连接到概率估计器，用于估计多个路径中的给定一个路径是最佳执行路径的概率值。

公开(公告)号：US20050004192A1

公开(公告)日：2005-01-06

申请号：US10682647

申请日：2003-10-08

申请人： Jonathan Bloom ,  Thomas Bailey

发明人： Jonathan Bloom ,  Thomas Bailey

IPC分类号： A61K31/195 ,  A61K31/24 ,  A61K31/41 ,  A61P31/12 ,  C07C235/24 ,  C07C237/04 ,  C07C255/54 ,  C07C323/60 ,  C07D257/04

CPC分类号： A61K31/195 ,  A61K31/24 ,  A61K31/41 ,  C07C235/24 ,  C07C237/04 ,  C07C255/54 ,  C07C323/60 ,  C07D257/04

摘要： The present invention provides pharmaceutical compositions useful in treating hepatitis C infection. The present invention also provides methods of treating hepatitis C infection by administering to a mammal the pharmaceutical compositions of the present invention.

摘要翻译： 本发明提供可用于治疗丙型肝炎感染的药物组合物。 本发明还提供了通过向哺乳动物施用本发明的药物组合物来治疗丙型肝炎感染的方法。

公开(公告)号：US06407249B1

公开(公告)日：2002-06-18

申请号：US09684011

申请日：2000-12-29

申请人： Jonathan Bloom ,  Kevin Curran ,  Martin DiGrandi ,  Russell Dushin ,  Thomas Jones ,  Stanley Lang ,  Adma Ross ,  Eugene A. Terefenko ,  Bryan O'Hara

发明人： Jonathan Bloom ,  Kevin Curran ,  Martin DiGrandi ,  Russell Dushin ,  Thomas Jones ,  Stanley Lang ,  Adma Ross ,  Eugene A. Terefenko ,  Bryan O'Hara

IPC分类号： A61K31341

CPC分类号： C07D213/75 ,  C07D213/81 ,  C07D405/12 ,  C07D417/12

摘要： Compounds of the formula: wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, —CN, —NO2, —CO2R6, —COR6, —OR6, —SR6, —SOR6, —SO2R6, —CONR7R8, —NR6N(R7R8), —N(R7R8) or W—Y—(CH2)n—Z provided that at least one of R1-R5 is not hydrogen; or R2 and R3 or R3 and R4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; R9-R12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R9 and R10 or R11 and R12 may be taken together to form aryl of 5 to 7 carbon atoms; provided that at least one of R9-12 is not hydrogen; W is O, NR6, or is absent; Y is —(CO)— or —(CO2)—, or is absent; Z is alkyl of 1 to 4 carbon atoms, —CN, —CO2R6, COR6, —CONR7R8, —OCOR6, —NR6COR7, —OCONR6, —OR6, —SR6, —SOR6, —SO2R6, SR6N(R7R8), —N(R7R3R) or phenyl; G is a monocyclic heteroaryl; X is a bond, —NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6 useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

公开(公告)号：US06335350B1

公开(公告)日：2002-01-01

申请号：US09447005

申请日：1999-11-22

申请人： Jonathan Bloom ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Bryan O'Hara

发明人： Jonathan Bloom ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Bryan O'Hara

IPC分类号： C07D21126

CPC分类号： C07D213/75 ,  C07C335/20 ,  C07D207/456 ,  C07D209/42 ,  C07D215/16 ,  C07D217/12 ,  C07D241/24 ,  C07D249/04 ,  C07D261/18 ,  C07D277/56 ,  C07D285/06 ,  C07D307/84 ,  C07D333/38

摘要： Compounds of the formula: are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

摘要翻译： 下式的化合物可用于治疗与疱疹病毒相关的疾病，包括人巨细胞病毒，单纯疱疹病毒，爱泼斯坦 - 巴尔病毒，水痘带状疱疹病毒，人疱疹病毒-6和-7以及卡波西疱疹病毒。

公开(公告)号：US06262090B1

公开(公告)日：2001-07-17

申请号：US09444896

申请日：1999-11-22

申请人： Jonathan Bloom ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Bryan O'Hara

发明人： Jonathan Bloom ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Bryan O'Hara

IPC分类号： A61K3144

CPC分类号： C07D333/02 ,  C07D207/34 ,  C07D211/72 ,  C07D213/44 ,  C07D235/26 ,  C07D307/02

摘要： Compounds of the formula wherein A is heteroaryl; R9-R12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R9 and R10 or R11 and R12 may be taken together to form aryl of 5 to 7 carbon atoms; W is O, NR6, or is absent; G is aryl or heteroaryl; and X is a bond X is a bond, —NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; and J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; or a pharmaceutical acceptable salt thereof, useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

摘要翻译： 式Ⅳa的化合物是杂芳基; R 9 -R 12独立地是氢，1至4个碳原子的烷基，1至4个碳原子的全卤代烷基，卤素，1至4个碳原子的烷氧基或氰基，或R 9和R 10或R 11和 R 12可以一起形成5至7个碳原子的芳基; W是O，NR 6或不存在; G是芳基或杂芳基; X为键，X为碳原子数为1〜6的烷基，碳原子数为1〜6的烯基，碳原子数为1〜6的烷氧基，碳原子数为1〜6的硫代烷基，碳原子数为1〜6的烷基氨基 原子或（CH）J; 且J为1至6个碳原子的烷基，3至7个碳原子的环烷基，苯基或苄基; andn是1〜6的整数; 或其药学上可接受的盐，其可用于治疗与疱疹病毒相关的疾病，包括人巨细胞病毒，单纯疱疹病毒，爱泼斯坦 - 巴尔病毒，水痘带状疱疹病毒，人疱疹病毒-6和-7以及卡波西疱疹病毒。