发明授权
- 专利标题: Diaminopyridine-containing thiourea inhibitors of herpes virus
- 专利标题(中): 含二氨基吡啶的疱疹病毒的硫脲抑制剂
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申请号: US09669943申请日: 2000-09-26
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公开(公告)号: US06271236B1公开(公告)日: 2001-08-07
- 发明人: Jonathan Bloom , Martin DiGrandi , Russell Dushin , Stanley Lang , Bryan O'Hara
- 申请人: Jonathan Bloom , Martin DiGrandi , Russell Dushin , Stanley Lang , Bryan O'Hara
- 主分类号: C07D40102
- IPC分类号: C07D40102
摘要:
Compounds of the formula wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, —CN, —NO2, —CO2R6, —COR6, —OR6, —SR6, —SOR6, —SO2R6, —CONR7R8, —NR6N(R7R8), —N(R7R8) or W—Y—(CH2)n—Z; or R2 and R3 or R3 and R4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; A is heteroaryl.
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