发明授权
- 专利标题: Support for high performance affinity chromatography and other uses
- 专利标题(中): 支持高性能亲和层析等用途
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申请号: US09205750申请日: 1998-12-04
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公开(公告)号: US06277489B1公开(公告)日: 2001-08-21
- 发明人: Nicholas Abbott , Pieter Stroeve , Timothy B. Dubrovsky , Zhizhong Hou
- 申请人: Nicholas Abbott , Pieter Stroeve , Timothy B. Dubrovsky , Zhizhong Hou
- 主分类号: B32B516
- IPC分类号: B32B516
摘要:
Multilayered particulate materials are formed by coating a particulate substrate with a metal and adsorbing an organic layer comprising a recognition moiety onto the metal film. The recognition moiety interacts with an analyte of interest allowing for its detection, purification, etc. Suitable recognition moieties can be selected from a range of species including, small molecules, polymers and biomolecules and the like. The novel particulate materials of the invention can be utilized in an array of methods including, ion-exchange, ion-selective ion-exchange, assays, affinity dialysis, size exclusion dialysis, as supports in solid phase synthesis, combinatorial synthesis and screening of compound libraries and the like.