发明授权
US06288072B1 Camptothecin &bgr;-alanine esters with topoisomerase I inhibition
有权
喜树碱β-丙氨酸酯与拓扑异构酶I抑制作用
- 专利标题： Camptothecin &bgr;-alanine esters with topoisomerase I inhibition
- 专利标题（中）： 喜树碱β-丙氨酸酯与拓扑异构酶I抑制作用
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申请号： US09474099申请日： 1999-12-29
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公开(公告)号： US06288072B1公开(公告)日： 2001-09-11
- 发明人: Monroe E. Wall , Mansukh C. Wani , Govindarajan Manikumar , Neelakantan Balasubramanian , Dolatrai Vyas
- 申请人： Monroe E. Wall , Mansukh C. Wani , Govindarajan Manikumar , Neelakantan Balasubramanian , Dolatrai Vyas
- 主分类号： C07D47112
- IPC分类号： C07D47112
摘要：
&bgr;-Alanine esters of camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.