A method for optimizing an integrated circuit uses a dominant time constant of a transition of the circuit. A physical layout of the circuit is characterized in terms of design parameters. The circuit is modeled by a conductance matrix G and a capacitance matrix C, wherein G and C are affine functions of the design parameters. The optimization method comprises the step of finding the values of the design parameters that optimize a property of the circuit while simultaneously enforcing a constraint that the dominant time constant must be less than a maximum value tmax. Mathematically, the constraint on the dominant time constant can be written: tmax G−C≧0. The optimization method can be used when the circuit has a non-tree topology. Furthermore, when the design parameters comprise variables that relate to sizes of elements of the circuit, a topology of the circuit is optimized by the optimization method. In some embodiments the circuit is optimized for a plurality of transitions, and in some embodiments the design parameters are subject to design constraints.