发明授权
US06297400B1 Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol
有权
从新型二酰氨基二醇合成四氨基大环配体
- 专利标题： Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol
- 专利标题（中）： 从新型二酰氨基二醇合成四氨基大环配体
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申请号： US09347435申请日： 1999-07-02
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公开(公告)号： US06297400B1公开(公告)日： 2001-10-02
- 发明人: James E. Deline , Michael M. Ott
- 申请人： James E. Deline , Michael M. Ott
- 主分类号： C07C23303
- IPC分类号： C07C23303
摘要：
A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C15H30N2O4 and is prepared by reacting a first quantity of 2-amino-2-methyl-1-propanol with a second quantity of a di-substituted malonyl dichloride (i.e., diethylmalonyl dichloride), preferably in ethyl acetate as solvent. A tetraamido macrocycle is prepared from the diamidodiol in two steps by oxidizing the diamidodiol to form a diacid followed by coupling using a known procedure of the diacid with an aryl diamine (e.g., 1,2-diaminobenzene)to yield the tetraamido macrocycle.
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