A method of generating quality matrices indicating a relationship between critical to quality characteristics and key control parameters for levels of a process. A plurality of rows of a first matrix are designated as critical to quality characteristics and a plurality of columns of the first matrix are designated as key control parameters. Each critical to quality characteristic is assigned a critical to quality weight. An interaction weight is assigned between at least one critical to quality characteristic and at least one key control parameter. A score is then generated for at least one key control parameter in response to said critical to quality weight and said interaction weight.